? Center for In Vivo Imaging and Therapeutics The Center for In Vivo Imaging and Therapeutics (CIVIT) is an SJCCC-managed Shared Resource with the overarching goal of providing cutting-edge imaging and image-guided therapy technologies to advance preclinical cancer modeling research. As part of the SJCCC Strategic Plan, the HMP, DBSTP, NBTP, and CBP prioritized enhanced animal modeling as a central requirement for their preclinical research endeavors, with CIVIT at the center of these plans. CIVIT plays a major role in advancing SJCCC preclinical research by offering leading surgical and imaging expertise, allowing Program members to readily model and survey genetic and orthotopic-implant models of brain tumors, solid tumors, and leukemias. CIVIT partners with SJCCC members to provide consultative and technical expertise in modeling and conducting experiments for their preclinical research. The core also offers seminars to educate users about new preclinical imaging applications and technologies. CIVIT is directed by Dr. Walter Akers, an NCI R50-funded veterinarian and biomedical engineer with more than 11 years of experience in cancer imaging and therapy research. He is supported by 1 staff scientist and 6 highly skilled research technologists to provide imaging, surgery, and therapeutic services, and partner with SJCCC groups in planning and performing experiments to ensure animal studies are conducted at the highest standard. The impact of the CIVIT on the cancer research of the Programs is evidenced by the high level of collaborative publications and key scientific contributions in high-impact journals such as Blood (n=5), Nature Genetics (n=3), and Cancer Cell (n=6). During the current funding period, 66 publications from January 2013?December 2017 used the CIVIT, representing 28 (42%) interprogrammatic and 33 (50%) intraprogrammatic collaborations. These included publications from 4 of the 5 Programs: DBSTP (n=16), HMP (n=25), CBP (n=34), and NBTP (n=25). During the index year (FY2017), 94% of all investigators using the CIVIT were SJCCC members (49/52). Goals for the next period include upgrading high-frequency ultrasounds (Vevo 3100, Visualsonics) to provide state-of-the-art capabilities for image-guided injections and tumor volume measurement; obtaining a fluorescence-capable surgical microscope to optimize brainstem O-PDX implantation and image-guided resections of O-PDX tumors in mice; and upgrading the IGRT system with BLI capability (Muriglo, Xstrahl) to enable tumor-selective radiation for preclinical trials. These advanced technologies will ensure continued high-level support of the preclinical research of the SJCCC Programs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA021765-40
Application #
9632007
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-03-01
Budget End
2020-02-29
Support Year
40
Fiscal Year
2019
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Dove, Austin P; Manole, Bogdan-Alexandru; Wakefield, Daniel V et al. (2018) Managing local-regional failure in children with high-risk neuroblastoma: A single institution experience. Pediatr Blood Cancer 65:e27408
Kurmasheva, Raushan T; Kurmashev, Dias; Reynolds, C Patrick et al. (2018) Initial testing (stage 1) of M6620 (formerly VX-970), a novel ATR inhibitor, alone and combined with cisplatin and melphalan, by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 65:
Chamdine, Omar; Elhawary, Ghada Ahmad Saad; Alfaar, Ahmad Samir et al. (2018) The incidence of brainstem primitive neuroectodermal tumors of childhood based on SEER data. Childs Nerv Syst 34:431-439
Heitzer, Andrew M; Ashford, Jason M; Harel, Brian T et al. (2018) Computerized assessment of cognitive impairment among children undergoing radiation therapy for medulloblastoma. J Neurooncol :
Robinson, Katherine M; Yang, Wenjian; Haidar, Cyrine E et al. (2018) Concordance between glucose-6-phosphate dehydrogenase (G6PD) genotype and phenotype and rasburicase use in patients with hematologic malignancies. Pharmacogenomics J :
Teitz, Tal; Fang, Jie; Goktug, Asli N et al. (2018) CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss. J Exp Med 215:1187-1203
Binder, Randall J; Hatfield, M Jason; Chi, Liying et al. (2018) Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors. Eur J Med Chem 149:79-89
Slayton, William B; Schultz, Kirk R; Kairalla, John A et al. (2018) Dasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622. J Clin Oncol 36:2306-2314
Donohoe, Clare; Bosi, Judy K; Sykes, April et al. (2018) Clinical Characteristics of Children and Adolescents Undergoing Hematopoietic Cell Transplantation Who Develop Oral Mucositis. Oncol Nurs Forum 45:457-462
Green, Daniel M; Wang, Mingjuan; Krasin, Matthew J et al. (2018) Serum ALT elevations in survivors of childhood cancer. A report from the St. Jude Lifetime Cohort Study. Hepatology :

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