The Vermont Cancer Center (VCC), in Burlington, Vermont, is a matrix- based Cancer Center located on the campus of the University of Vermont. Since its founding in 1974, the Vermont Cancer Center has ben committed to its mission in research, education and service to the people of the Vermont and their neighbors in northern New York. Although one of the smallest NCI-designated Comprehensive Cancer Centers, its central role in the UVM College of Medicine, and the unusual nature of the rural and relatively stable population it serves, have created an ideal environment for integration of basic, clinical and population-directed research related to cancer. Four Research Programs are presented. Two are strongly grounded in basic research (1-Genome Stability and Expression Research Program; 2- Cell Signaling and Growth Control Research Program) but have clear links to cancer as a disease through studies at the 1) molecular/mechanistic, or 2) the cellular/biological level. The Clinical Research Program has an emphasis on therapeutic and translational research with focused interests on breast, gynecologic and genitourinary cancers. Finally, the Center's Cancer Prevention and Control Research Program conducts a range of population-based studies in primary and secondary cancer prevention, with a strong emphasis on behavioral research. Focused interests in breast cancer, tobacco control, and genetic risk factors for cancer have provided the foundation for this well- established program. Nine-Shared Resources or support services are presented, including two that are new to the Center. They include: Cell Imaging Facility, DNA Analysis Facility, Fly Cytometry Facility, Glassware Washing Facility, Molecular Modeling Facility, Molecular Methods Core, Biostatistics Core, Clinical Research Management Core, and Protocol-specific Support. Developmental funds for pilot studies and recruitment of investigators critical to the Center's research mission are also requested.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Vermont & St Agric College
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Kelemen, Linda E; Abbott, Sarah; Qin, Bo et al. (2017) Cigarette smoking and the association with serous ovarian cancer in African American women: African American Cancer Epidemiology Study (AACES). Cancer Causes Control 28:699-708
Long, Patrick M; Tighe, Scott W; Driscoll, Heather E et al. (2015) Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest. J Cell Physiol 230:1929-43
Tsen, Andrew R; Long, Patrick M; Driscoll, Heather E et al. (2014) Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. Int J Cancer 134:1300-10
Wagner, Darcy E; Bonenfant, Nicholas R; Parsons, Charles S et al. (2014) Comparative decellularization and recellularization of normal versus emphysematous human lungs. Biomaterials 35:3281-97
Long, Patrick M; Tighe, Scott W; Driscoll, Heather E et al. (2013) Acetate supplementation induces growth arrest of NG2/PDGFR?-positive oligodendroglioma-derived tumor-initiating cells. PLoS One 8:e80714
Sokocevic, Dino; Bonenfant, Nicholas R; Wagner, Darcy E et al. (2013) The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs. Biomaterials 34:3256-69
Long, Patrick M; Moffett, John R; Namboodiri, Aryan M A et al. (2013) N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells. J Biol Chem 288:26188-200
Bonenfant, Nicholas R; Sokocevic, Dino; Wagner, Darcy E et al. (2013) The effects of storage and sterilization on de-cellularized and re-cellularized whole lung. Biomaterials 34:3231-45
Murray, Janet M; Messier, Terri; Rivers, Jami et al. (2012) VDJ recombinase-mediated TCR ? locus gene usage and coding joint processing in peripheral T cells during perinatal and pediatric development. J Immunol 189:2356-64
Wallis, John M; Borg, Zachary D; Daly, Amanda B et al. (2012) Comparative assessment of detergent-based protocols for mouse lung de-cellularization and re-cellularization. Tissue Eng Part C Methods 18:420-32

Showing the most recent 10 out of 219 publications