Abstract

) The VCC Molecular Methods Shared Resource will be a new shared resource. The goal is to centralize efforts to develop and extend expertise in cell and molecular techniques and thereby enhance the research power of VCC investigators. A major goal will be to explore and take full advantage of the capabilities of several new instruments available to VCC investigators as they are relevant to the programmatic research, and to help design and implement new approaches toward current research goals. In planning this core, VCC investigators identified priority areas for techniques development that are needed to circumvent the current rate-limiting steps in experimental design and/or data collection. These include: 1. ectopic gene expression, 2. quantitative analysis of gene expression and 3. analysis of protein and gene expression in animal and human tissue samples. A major function of this core will be in methods and assay development. The goal is to consolidate resources needed to develop and extend techniques for analyzing levels and consequences of changes in gene expression. In doing so, this new core facility can significantly enhance the research potential of VCC investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA022435-19
Application #
6563767
Study Section
Subcommittee G - Education (NCI)
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
19
Fiscal Year
2002
Total Cost
$78,870
Indirect Cost

  Institution

Name
University of Vermont & St Agric College
Department
Type
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405

  Publications

Kelemen, Linda E; Abbott, Sarah; Qin, Bo et al. (2017) Cigarette smoking and the association with serous ovarian cancer in African American women: African American Cancer Epidemiology Study (AACES). Cancer Causes Control 28:699-708
Long, Patrick M; Tighe, Scott W; Driscoll, Heather E et al. (2015) Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest. J Cell Physiol 230:1929-43
Tsen, Andrew R; Long, Patrick M; Driscoll, Heather E et al. (2014) Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. Int J Cancer 134:1300-10
Wagner, Darcy E; Bonenfant, Nicholas R; Parsons, Charles S et al. (2014) Comparative decellularization and recellularization of normal versus emphysematous human lungs. Biomaterials 35:3281-97
Long, Patrick M; Tighe, Scott W; Driscoll, Heather E et al. (2013) Acetate supplementation induces growth arrest of NG2/PDGFR?-positive oligodendroglioma-derived tumor-initiating cells. PLoS One 8:e80714
Sokocevic, Dino; Bonenfant, Nicholas R; Wagner, Darcy E et al. (2013) The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs. Biomaterials 34:3256-69
Long, Patrick M; Moffett, John R; Namboodiri, Aryan M A et al. (2013) N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells. J Biol Chem 288:26188-200
Bonenfant, Nicholas R; Sokocevic, Dino; Wagner, Darcy E et al. (2013) The effects of storage and sterilization on de-cellularized and re-cellularized whole lung. Biomaterials 34:3231-45
Murray, Janet M; Messier, Terri; Rivers, Jami et al. (2012) VDJ recombinase-mediated TCR ? locus gene usage and coding joint processing in peripheral T cells during perinatal and pediatric development. J Immunol 189:2356-64
Wallis, John M; Borg, Zachary D; Daly, Amanda B et al. (2012) Comparative assessment of detergent-based protocols for mouse lung de-cellularization and re-cellularization. Tissue Eng Part C Methods 18:420-32

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