The Behavioral and Field Research Core (BFRC) is designed to facilitate the integration of communication and behavioral research across the Institute including work in epidemiology, cancer prevention, clinical and developmental therapeutics, palliative care, and genetics. The BFRC is grouped in the Population Research Core Cluster along with the Epidemiology Research Core. The Core offers expertise in communication science and behavioral research methodologies; design and evaluation of evidence-based social and behavioral interventions (including social marketing as a systematic approach to population level behavior change); social network methodology and analysis; quality of life measurement utilizing the most appropriate instruments; ecological momentary assessment (EMA techniques provide methods by which a research participant can report on symptoms, affect, behavior, and cognitions proximal to the experience, and these reports are obtained many times throughout the study); electronic daily diaries (QOL continues to be a critical factor in developmental therapeutic trials); and community engagement research, particularly related to health disparities. The Core maintains an active network of community organization partnerships across the Institute's catchment area. Community partners participate in research advisory committees and community advisory committees, providing community perspective, input and facilitating access to the populations they serve. Through these partnerships, the Core facilitates community access for Institute researchers, thus serving to assist in the translation and dissemination of cancer research. Resources available through BFRC include real-time video recording and coding of clinical interactions (including equipment, software and expertise), access to an extensive video archive for communication and behavioral studies, geographical and population tracking/mapping capabilities, community research participant registries, access to comprehensive national datasets (e.g. HINTS), as well as an extensive bank of clinical and social/behavioral instruments and measures. The services provided by the BFRC have contributed to 32 peer-reviewed publications during the current review period. As an example, the BFRC provided all regulatory tasks, recruitment, data collection, video capture, post-production editing, and coding for Dr. Penner's (PSDR) work demonstrating the importance of recognizing and understanding how the distinct dynamics of racially concordant and discordant interactions affect medical encounters and outcomes, (Hagiwara N, Soc SciMed, 2013).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA022453-34
Application #
8997275
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2016-02-01
Budget End
2016-11-30
Support Year
34
Fiscal Year
2016
Total Cost
$39,313
Indirect Cost
$13,674
Name
Wayne State University
Department
Type
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Su, Yongwei; Li, Xinyu; Ma, Jun et al. (2018) Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo. Biochem Pharmacol 148:13-26
Bonomi, Robin; Popov, Vadim; Laws, Maxwell T et al. (2018) Molecular Imaging of Sirtuin1 Expression-Activity in Rat Brain Using Positron-Emission Tomography-Magnetic-Resonance Imaging with [18F]-2-Fluorobenzoylaminohexanoicanilide. J Med Chem 61:7116-7130
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Modi, Dipenkumar; Al-Kadhimi, Zaid; Chen, Wei et al. (2018) A phase II study of tacrolimus and thymoglobulin as graft-versus-host-disease prophylaxis in related donor allogeneic hematopoietic cell transplantation. Am J Hematol 93:E96-E98
Patki, Mugdha; McFall, Thomas; Rosati, Rayna et al. (2018) Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor. Sci Rep 8:16006
Teslow, Emily A; Bao, Bin; Dyson, Greg et al. (2018) Exogenous IL-6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild-type, African American PCa cells. Mol Oncol 12:1138-1152
Rathinam, Rajamani; Rosati, Rita; Jamesdaniel, Samson (2018) CRISPR/Cas9-mediated knockout of Lim-domain only four retards organ of Corti cell growth. J Cell Biochem 119:3545-3553
Munkanatta Godage, Dhanushka N P; VanHecke, Garrett C; Samarasinghe, Kusal T G et al. (2018) SMYD2 glutathionylation contributes to degradation of sarcomeric proteins. Nat Commun 9:4341
Han, Jing; Li, Yue; Liu, Xiuli et al. (2018) Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo. PLoS One 13:e0193031
Kim, Seongho; Wong, Weng Kee (2018) Discussion on Optimal treatment allocations in space and time for on-line control of an emerging infectious disease. J R Stat Soc Ser C Appl Stat 67:778-779

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