The Epidemiology Research Core (ERC) supports population-based cancer research in metropolitan Detroit. The ERC is grouped in the Population Research Core Cluster along with the Behavioral and Field Research Core. The ERC is located within the Metropolitan Detroit Cancer Surveillance System (MDCSS), an NCI-funded population-based Surveillance, Epidemiology and End Results (SEER) Program central cancer registry. The MDCSS is located at Wayne State University (WSU), under the umbrella of the Karmanos Cancer Institute (KCI). Both Detroit and national SEER data contain detailed histological and demographic information, primary treatment and survival data for all patients with newly-diagnosed, invasive cancer in their respective geographic coverage areas. The ERC provides necessary support for access to and utilization of the very complex local and national SEER data for research. The Core also provides epidemiology consulting and collaborates with KCI members conducting investigations in cancer prevention, etiology, treatment and outcomes. This mission is achieved through services including rapid case ascertainment; collection of medical records and biospecimens; abstracting medical records for study-specific information; linkage of datasets to patient data for diagnostic, treatment, and outcomes research; identifying population-based control populations; research support and training for studies involving participant recruitment and interviewing; data queries and epidemiologic expertise and collaboration in the conduct of population-based investigations of cancer. The ERC benefits KCI by centralizing access to SEER data and standardizing patient, physician and hospital interactions for studies using SEER data for population-based research. The metropolitan Detroit population contains a large number of minorities, with 22% of the ~25,000 annual cancer diagnoses in the SEER catchment area being African American. This makes the population ideal for the study of health disparities. The ERC contributes significantly to the population-based research conducted at KCI, primarily through the identification of eligible participants and collection of data and biospecimens on these participants, evidenced in part by the 91 publications accomplished with support of the ERC during the current grant period.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Wayne State University
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Pollack, Murray M; Holubkov, Richard; Reeder, Ron et al. (2018) PICU Length of Stay: Factors Associated With Bed Utilization and Development of a Benchmarking Model. Pediatr Crit Care Med 19:196-203
Bao, Xun; Wu, Jianmei; Sanai, Nader et al. (2018) A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor. J Pharm Anal 8:20-26
Matherly, Larry H; Hou, Zhanjun; Gangjee, Aleem (2018) The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer. Cancer Chemother Pharmacol 81:1-15
Ali, Arif N; Zhang, Peixin; Yung, W K Alfred et al. (2018) NRG oncology RTOG 9006: a phase III randomized trial of hyperfractionated radiotherapy (RT) and BCNU versus standard RT and BCNU for malignant glioma patients. J Neurooncol 137:39-47
Heath, Elisabeth I; Lynce, Filipa; Xiu, Joanne et al. (2018) Racial Disparities in the Molecular Landscape of Cancer. Anticancer Res 38:2235-2240
McFall, Thomas; McKnight, Brooke; Rosati, Rayna et al. (2018) Progesterone receptor A promotes invasiveness and metastasis of luminal breast cancer by suppressing regulation of critical microRNAs by estrogen. J Biol Chem 293:1163-1177
McKnight, Brooke N; Viola-Villegas, Nerissa T (2018) Monitoring Src status after dasatinib treatment in HER2+ breast cancer with 89Zr-trastuzumab PET imaging. Breast Cancer Res 20:130
Greenwald, Mark K; Ruterbusch, Julie J; Beebe-Dimmer, Jennifer L et al. (2018) Risk of incident claims for chemotherapy-induced peripheral neuropathy among women with breast cancer in a Medicare population. Cancer :
Dyson, Greg; Farran, Batoul; Bolton, Susan et al. (2018) The extrema of circulating miR-17 are identified as biomarkers for aggressive prostate cancer. Am J Cancer Res 8:2088-2095
Shah, Seema; Brock, Ethan J; Jackson, Ryan M et al. (2018) Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation. Neoplasia 20:951-963

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