The Epidemiology Research Core (ERC) supports population-based cancer research in metropolitan Detroit. The ERC is grouped in the Population Research Core Cluster along with the Behavioral and Field Research Core. The ERC is located within the Metropolitan Detroit Cancer Surveillance System (MDCSS), an NCI-funded population-based Surveillance, Epidemiology and End Results (SEER) Program central cancer registry. The MDCSS is located at Wayne State University (WSU), under the umbrella of the Karmanos Cancer Institute (KCI). Both Detroit and national SEER data contain detailed histological and demographic information, primary treatment and survival data for all patients with newly-diagnosed, invasive cancer in their respective geographic coverage areas. The ERC provides necessary support for access to and utilization of the very complex local and national SEER data for research. The Core also provides epidemiology consulting and collaborates with KCI members conducting investigations in cancer prevention, etiology, treatment and outcomes. This mission is achieved through services including rapid case ascertainment; collection of medical records and biospecimens; abstracting medical records for study-specific information; linkage of datasets to patient data for diagnostic, treatment, and outcomes research; identifying population-based control populations; research support and training for studies involving participant recruitment and interviewing; data queries and epidemiologic expertise and collaboration in the conduct of population-based investigations of cancer. The ERC benefits KCI by centralizing access to SEER data and standardizing patient, physician and hospital interactions for studies using SEER data for population-based research. The metropolitan Detroit population contains a large number of minorities, with 22% of the ~25,000 annual cancer diagnoses in the SEER catchment area being African American. This makes the population ideal for the study of health disparities. The ERC contributes significantly to the population-based research conducted at KCI, primarily through the identification of eligible participants and collection of data and biospecimens on these participants, evidenced in part by the 91 publications accomplished with support of the ERC during the current grant period.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Wayne State University
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Hastert, T A; de Oliveira Otto, M C; LĂȘ-Scherban, F et al. (2018) Association of plasma phospholipid polyunsaturated and trans fatty acids with body mass index: results from the Multi-Ethnic Study of Atherosclerosis. Int J Obes (Lond) 42:433-440
Bock, Cathryn H; Jay, Allison M; Dyson, Gregory et al. (2018) The effect of genetic variants on the relationship between statins and breast cancer in postmenopausal women in the Women's Health Initiative observational study. Breast Cancer Res Treat 167:741-749
Mittal, Sandeep; Klinger, Neil V; Michelhaugh, Sharon K et al. (2018) Alternating electric tumor treating fields for treatment of glioblastoma: rationale, preclinical, and clinical studies. J Neurosurg 128:414-421
Park, Hyo K; Schildkraut, Joellen M; Alberg, Anthony J et al. (2018) Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: a case-control study. Cancer Causes Control 29:1081-1091
Heyza, Joshua; Lei, Wen; Watza, Donovan et al. (2018) Identification and characterization of synthetic viability with ERCC1 deficiency in response to interstrand crosslinks in lung cancer. Clin Cancer Res :
Bonomi, Robin; Popov, Vadim; Laws, Maxwell T et al. (2018) Molecular Imaging of Sirtuin1 Expression-Activity in Rat Brain Using Positron-Emission Tomography-Magnetic-Resonance Imaging with [18F]-2-Fluorobenzoylaminohexanoicanilide. J Med Chem 61:7116-7130
Paximadis, Peter; Beebe-Dimmer, Jennifer L; George, Julie et al. (2018) Comparing Treatment Strategies for Stage I Small-cell lung Cancer. Clin Lung Cancer 19:e559-e565
Su, Yongwei; Li, Xinyu; Ma, Jun et al. (2018) Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo. Biochem Pharmacol 148:13-26
Patki, Mugdha; McFall, Thomas; Rosati, Rayna et al. (2018) Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor. Sci Rep 8:16006
Teslow, Emily A; Bao, Bin; Dyson, Greg et al. (2018) Exogenous IL-6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild-type, African American PCa cells. Mol Oncol 12:1138-1152

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