The purpose of the Biobanking and Correlative Sciences (BCS) Core is to enhance the peer reviewed, funded research activities of KCI members whose research requires IRB-approved access to patient tissue for preclinical and clinical studies and to support clinical trials by managing tissue specimens and providing circulating tumor cell counting. The BCS Core is grouped in the Cross Disciplinary Research Core Cluster which, in addition to the BCS Core, includes the Biostatistics, Genomics, and Pharmacology Cores. The BCS Core provides KCI investigators with high quality, well-annotated tumor tissue specimens for pre- clinical studies and coordinates requests for tumor tissues with the Genomics, Pharmacology and Proteomics Cores. Disease site-specific pathologists review tissues for selection of appropriate samples. This ensures there is appropriate and adequate tissue in the amounts and numbers needed for a given study to provide biologically meaningful results as determined by the Biostatistics Core. Institutional funds support the contributions of the pathologists. Fresh frozen specimens in the KCI Biobank are stored in eight -80?C freezers, which are temperature monitored and have back up emergency power. All specimens are barcoded and stored in cryosafe containers. Secured cabinets store formalin-fixed paraffin embedded (FFPE) specimens and any prepared slides from the biospecimens. Each biospecimen is logged into the KCI database, OnCore, with its precise location, associated informed consent, pathology report, and amount of available tissue. Histology services are supported by a tissue processor, a tissue embedder, microtomes, a cryostat, and other ancillary histology equipment. For pharmacodynamic assays, the core contains a Janssen Cell Search Circulating Tumor Cell system, which enables investigators to enumerate and/or isolate circulating tumor cells. The services provided by the Biobanking and Correlative Sciences Core have contributed to 21 peer- reviewed publications during the current review period.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA022453-38
Application #
9836635
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
38
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Bock, Cathryn H; Jay, Allison M; Dyson, Gregory et al. (2018) The effect of genetic variants on the relationship between statins and breast cancer in postmenopausal women in the Women's Health Initiative observational study. Breast Cancer Res Treat 167:741-749
Hastert, T A; de Oliveira Otto, M C; LĂȘ-Scherban, F et al. (2018) Association of plasma phospholipid polyunsaturated and trans fatty acids with body mass index: results from the Multi-Ethnic Study of Atherosclerosis. Int J Obes (Lond) 42:433-440
Heyza, Joshua; Lei, Wen; Watza, Donovan et al. (2018) Identification and characterization of synthetic viability with ERCC1 deficiency in response to interstrand crosslinks in lung cancer. Clin Cancer Res :
Mittal, Sandeep; Klinger, Neil V; Michelhaugh, Sharon K et al. (2018) Alternating electric tumor treating fields for treatment of glioblastoma: rationale, preclinical, and clinical studies. J Neurosurg 128:414-421
Park, Hyo K; Schildkraut, Joellen M; Alberg, Anthony J et al. (2018) Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: a case-control study. Cancer Causes Control 29:1081-1091
Su, Yongwei; Li, Xinyu; Ma, Jun et al. (2018) Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo. Biochem Pharmacol 148:13-26
Bonomi, Robin; Popov, Vadim; Laws, Maxwell T et al. (2018) Molecular Imaging of Sirtuin1 Expression-Activity in Rat Brain Using Positron-Emission Tomography-Magnetic-Resonance Imaging with [18F]-2-Fluorobenzoylaminohexanoicanilide. J Med Chem 61:7116-7130
Paximadis, Peter; Beebe-Dimmer, Jennifer L; George, Julie et al. (2018) Comparing Treatment Strategies for Stage I Small-cell lung Cancer. Clin Lung Cancer 19:e559-e565
Modi, Dipenkumar; Al-Kadhimi, Zaid; Chen, Wei et al. (2018) A phase II study of tacrolimus and thymoglobulin as graft-versus-host-disease prophylaxis in related donor allogeneic hematopoietic cell transplantation. Am J Hematol 93:E96-E98
Patki, Mugdha; McFall, Thomas; Rosati, Rayna et al. (2018) Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor. Sci Rep 8:16006

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