TUMOR BIOLOGY AND MICROENVIRONMENT (TBM) ? ABSTRACT The Tumor Biology and Microenvironment (TBM) Program is a translational science program that aims to discover the cellular and molecular determinants that drive the initiation and progression of cancers through interactions with their microenvironments and develop and test innovative diagnostic and treatment strategies. This highly integrated Program includes 37 members from 13 departments and 4 schools at Wayne State University. TBM Program members, who conduct basic, preclinical, and clinical research, receive $4,468,183 in peer reviewed, cancer-related grant support, of which $1,943,419 is from the NCI. The TBM Program is organized along three major themes. The goal of the first theme is to explore biological processes that mediate the phenotypical plasticity, proliferation, and survival of tumor cells. Translational research is conducted to evaluate the potential clinical application of these molecular determinants as tumor markers and/or therapeutic targets. The second theme investigates mechanisms that enable tumor cells to overcome external barriers during invasion and metastasis. Our investigators assess the importance of factors that control extracellular proteolysis and signaling mechanisms that are being used by tumor cells to adapt to and subvert the microenvironment at primary and metastatic sites. The objective of the third theme is to develop new strategies to engage the immune system as powerful defenses against cancer. Research activities include the development of immune modulators and novel vehicles to optimally deliver immunotherapeutics, as well as the use of state-of-the art imaging modalities for monitoring the success to tumor immunotherapy. The TBM Program is led by Dr. Kay-Uwe Wagner as Program Leader and Dr. Asfar Azmi as Program Co-Leader. The Leader and Co-Leader are new since the last competitive renewal. All members of the TBM Program actively collaborate with members of the MI, MT, and PSDR Programs at KCI. Of the 484 manuscripts published between December 2015 and November 2019, 41% and 44% were intra- and inter-programmatic, respectively, and 61% were multi-institutional collaborations.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Special Emphasis Panel (ZCA1)
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Wayne State University
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Desai, Pinkal; Wallace, Robert; Anderson, Matthew L et al. (2018) An analysis of the effect of statins on the risk of Non-Hodgkin's Lymphoma in the Women's Health Initiative cohort. Cancer Med 7:2121-2130
White, Donna L; Hoogeveen, Ron C; Chen, Liang et al. (2018) A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women. Cancer Med 7:2180-2191
Shaik, Asra N; Ruterbusch, Julie J; Abdulfatah, Eman et al. (2018) Breast fibroadenomas are not associated with increased breast cancer risk in an African American contemporary cohort of women with benign breast disease. Breast Cancer Res 20:91
Farrell, Allison K; Slatcher, Richard B; Tobin, Erin T et al. (2018) Socioeconomic status, family negative emotional climate, and anti-inflammatory gene expression among youth with asthma. Psychoneuroendocrinology 91:62-67
Colacino, Justin A; Azizi, Ebrahim; Brooks, Michael D et al. (2018) Heterogeneity of Human Breast Stem and Progenitor Cells as Revealed by Transcriptional Profiling. Stem Cell Reports 10:1596-1609
Herroon, Mackenzie K; Rajagurubandara, Erandi; Diedrich, Jonathan D et al. (2018) Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin. Sci Rep 8:40
Guastella, Anthony R; Michelhaugh, Sharon K; Klinger, Neil V et al. (2018) Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors. J Neurooncol 139:239-249
Blocker, Stephanie J; Shields, Anthony F (2018) Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery. Mol Imaging Biol 20:340-351
Ramseyer, Vanesa D; Kimler, Victoria A; Granneman, James G (2018) Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes. Mol Metab 7:57-70
Li, Feng; Wang, Yongli; Li, Dapeng et al. (2018) Perspectives on the recent developments with green tea polyphenols in drug discovery. Expert Opin Drug Discov 13:643-660

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