Abstract

The Arizona Cancer Center (ACC) Cytogenetics Shared Service provides genetic characterization of normal and malignant cells in support of ACC research and collaborations, such as those with the National Human Genome Research Institute. Services include karyotyping and detailed chromosome analysis using fluorescence in situ hybridization (FISH). These services identify genetic abnormalities for detailed study and are an important quality control for cell lines. A database for prior karyotypes and FISH results is maintained and allows this shared services to compare current and past results to detect potential contaminants and detect genetic """"""""drift"""""""" in selected cell lines. By interfacing these results with resources of the Tissue Cultured Shared Service, unique cell lines developed by the ACC and """"""""public"""""""" cell lines with specific genetic abnormalities can be identified and provided to ACC investigators. The Cytogenetic Shared Service is the only facility providing detailed chromosome characterization of malignant cell on the Arizona Health Sciences Campus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023074-21
Application #
6269047
Study Section
Project Start
1998-08-14
Project End
1999-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
21
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Nguyen, Mike M; Martinez, Jessica A; Hsu, Chiu-Hsieh et al. (2018) Bioactivity and prostate tissue distribution of metformin in a preprostatectomy prostate cancer cohort. Eur J Cancer Prev 27:557-562
Zeltzer, Sebastian; Zeltzer, Carol A; Igarashi, Suzu et al. (2018) Virus Control of Trafficking from Sorting Endosomes. MBio 9:
Kohler, Lindsay N; Harris, Robin B; Oren, Eyal et al. (2018) Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma. Nutrients 10:
Jones, Kyle M; Pagel, Mark D; Cárdenas-Rodríguez, Julio (2018) Linearization improves the repeatability of quantitative dynamic contrast-enhanced MRI. Magn Reson Imaging 47:16-24
Bea, Jennifer W; Funk, Janet; Hetherington-Rauth, Megan et al. (2018) Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls. Obesity (Silver Spring) 26:1594-1602
Hornbrook, Mark C; Cobb, Martha D; Tallman, Nancy J et al. (2018) Costs of an ostomy self-management training program for cancer survivors. Psychooncology 27:879-885
Nakamya, Mary F; Ayoola, Moses B; Park, Seongbin et al. (2018) The Role of Cadaverine Synthesis on Pneumococcal Capsule and Protein Expression. Med Sci (Basel) 6:
Loescher, Lois J; Rains, Stephen A; Kramer, Sandra S et al. (2018) A Systematic Review of Interventions to Enhance Healthy Lifestyle Behaviors in Adolescents Delivered via Mobile Phone Text Messaging. Am J Health Promot 32:865-879
Knudsen, Erik S; Balaji, Uthra; Mannakee, Brian et al. (2018) Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility. Gut 67:508-520
Boese, Cody J; Nye, Jonathan; Buster, Daniel W et al. (2018) Asterless is a Polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state. Mol Biol Cell 29:2874-2886

Showing the most recent 10 out of 1336 publications