Abstract

The Arizona Cancer Center (ACC) Cytogenetics Shared Service provides genetic characterization of normal and malignant cells in support of ACC research and collaborations, such as those with the National Human Genome Research Institute. Services include karyotyping and detailed chromosome analysis using fluorescence in situ hybridization (FISH). These services identify genetic abnormalities for detailed study and are an important quality control for cell lines. A database for prior karyotypes and FISH results is maintained and allows this shared services to compare current and past results to detect potential contaminants and detect genetic """"""""drift"""""""" in selected cell lines. By interfacing these results with resources of the Tissue Cultured Shared Service, unique cell lines developed by the ACC and """"""""public"""""""" cell lines with specific genetic abnormalities can be identified and provided to ACC investigators. The Cytogenetic Shared Service is the only facility providing detailed chromosome characterization of malignant cell on the Arizona Health Sciences Campus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA023074-22S1
Application #
6295858
Study Section
Project Start
1999-07-01
Project End
2000-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
22
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

McLamarrah, Tiffany A; Buster, Daniel W; Galletta, Brian J et al. (2018) An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly. J Cell Biol 217:1217-1231
Mannakee, Brian K; Balaji, Uthra; Witkiewicz, Agnieszka K et al. (2018) Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors. Bioinformatics 34:1713-1718
Glassman, Caleb R; Parrish, Heather L; Lee, Mark S et al. (2018) Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex. Cell Rep 22:1263-1275
Nair, Uma S; Brady, Benjamin R; O'Connor, Patrick A et al. (2018) Factors Predicting Client Re-Enrollment in Tobacco Cessation Services in a State Quitline. Prev Chronic Dis 15:E126
Akam, E A; Utterback, R D; Marcero, J R et al. (2018) Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production. J Inorg Biochem 180:186-193
Hadinger, Kyle P; Marshalek, Joseph P; Sheeran, Paul S et al. (2018) Optimization of Phase-Change Contrast Agents for Targeting MDA-MB-231 Breast Cancer Cells. Ultrasound Med Biol 44:2728-2738
Han, Jiali; Li, Jianrong; Achour, Ikbel et al. (2018) Convergent downstream candidate mechanisms of independent intergenic polymorphisms between co-classified diseases implicate epistasis among noncoding elements. Pac Symp Biocomput 23:524-535
Galbraith, David W; Sliwinska, Elwira; Samadder, Partha (2018) Nuclear Cytometry: Analysis of the Patterns of DNA Synthesis and Transcription Using Flow Cytometry, Confocal Microscopy, and RNA Sequencing. Methods Mol Biol 1678:371-392
Nguyen, Mike M; Martinez, Jessica A; Hsu, Chiu-Hsieh et al. (2018) Bioactivity and prostate tissue distribution of metformin in a preprostatectomy prostate cancer cohort. Eur J Cancer Prev 27:557-562
Zeltzer, Sebastian; Zeltzer, Carol A; Igarashi, Suzu et al. (2018) Virus Control of Trafficking from Sorting Endosomes. MBio 9:

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