The Analytical Core Shared Service provides state of the art instrumentation for mass spectrometry-based chemical and biochemical analyses and personnel to assist investigators in the design and application of analytical methods and the interpretation of data. The Analytical Core is supported both by the Arizona Cancer Center (ACC) and the Southwest Environmental Health Sciences Center (SWEHSC) core grants. The objectives of the Analytical Core are to aid ACC and SWEHSC investigators: . In the identification of unknown compounds, . In the development of mass spectrometry based analytical methods, and . In the design of experiments and interpretation of analytical data. The Analytical Core is directed by Daniel C. Liebler, Ph.D., Associate Professor of Pharmacology and Toxicology and staffed by Thomas D. McClure, Ph.D., facility manager and one research specialist each supported by the ACC and SWEHSC core grants. Instrumentation in the Analytical Core includes a Finnigan TSQ7000 triple quadrupole instrument with electrospray and atmospheric pressure chemical ionization for HPLC-MS and HPLC-MS-MS work. This instrument is capable of protein and peptide sequence analysis as well as the analysis of a wide variety of biomolecules and macromolecules. The Analytical Core also houses a Finnigan MD-800 bench- top GC-MS system and a Hewlett Packard 1050 diode array HPLC system for method development. All analytical work is done by appointment. There is no charge assessed to ACC and SWEHC investigators for method development, whereas a flat per-sample fee is charge to recover costs of instrument service contracts.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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University of Arizona
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Casillas, Andrea L; Toth, Rachel K; Sainz, Alva G et al. (2018) Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents. Clin Cancer Res 24:169-180
Nair, Uma S; Bell, Melanie L; Yuan, Nicole P et al. (2018) Associations Between Comorbid Health Conditions and Quit Outcomes Among Smokers Enrolled in a State Quitline, Arizona, 2011-2016. Public Health Rep 133:200-206
Smithey, Megan J; Venturi, Vanessa; Davenport, Miles P et al. (2018) Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection. Proc Natl Acad Sci U S A 115:E6817-E6825
Maisel, Sabrina; Broka, Derrick; Schroeder, Joyce (2018) Intravesicular epidermal growth factor receptor subject to retrograde trafficking drives epidermal growth factor-dependent migration. Oncotarget 9:6463-6477
Daenthanasanmak, Anusara; Wu, Yongxia; Iamsawat, Supinya et al. (2018) PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. J Clin Invest 128:2787-2801
Augustus, Gaius J; Ellis, Nathan A (2018) Colorectal Cancer Disparity in African Americans: Risk Factors and Carcinogenic Mechanisms. Am J Pathol 188:291-303
Das, Lipsa; Gard, Jaime M C; Prekeris, Rytis et al. (2018) Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer. Mol Cancer Res 16:1319-1331
Cox, Christopher M; Lu, Ruifeng; Salcin, Kaan et al. (2018) The Endosomal Protein Endotubin Is Required for Enterocyte Differentiation. Cell Mol Gastroenterol Hepatol 5:145-156
?aniewski, Pawe?; Barnes, Dominique; Goulder, Alison et al. (2018) Linking cervicovaginal immune signatures, HPV and microbiota composition in cervical carcinogenesis in non-Hispanic and Hispanic women. Sci Rep 8:7593
Demark-Wahnefried, Wendy; Schmitz, Kathryn H; Alfano, Catherine M et al. (2018) Weight management and physical activity throughout the cancer care continuum. CA Cancer J Clin 68:64-89

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