Analytical Core

Chow, H-H. Sherry

Abstract

9.1.1 ANALYTICAL CORE SHARED SERVICE The overall mission of the Analytical Core Shared Service (ACSS) is to provide Cancer Center invesfigators with centralized resources and expertise in performing analytical chemistry assays and pharmacokinefic and pharmacodynamic data analysis and interpretation. Specifically, the Analytical Core Shared Service has the following aims: ?To provide support in developing and implementing chromatography-based bioanalytical assays for quarifification of cancer therapeufic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in biological specimens; ?To provide support in quanfitafive analysis of cancer therapeutic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in clinical and preclinical specimens; ?To provide support in developing proper sample handling and storage conditions for specimens collected for bioanalytical assays; ?To provide support in designing pharmacokinetic sample collection schedules and pharmacokinefic and pharmacodynamic data analysis and interpretafion. These services allow for the assessment of drug/nutrient/carcinogen exposure and disposition. Services provided by ACSS also support measurement of endogenous chemicals as surrogate cancer-risk biomarkers and pharmacodynamic endpoints. These lines of research have been essential to many projects currently being carried out at the Arizona Cancer Center, especially in programs with an emphasis in drug development and cancer prevenfion research.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 5P30CA023074-33
• Application #: 8279418
• Study Section: Subcommittee G - Education (NCI)
• Budget Start: 2011-07-01
• Budget End: 2012-06-30
• Support Year: 33
• Fiscal Year: 2011
• Total Cost: $140,931

Institution

• Name: University of Arizona
• DUNS #: 806345617
• City: Tucson
• State: AZ
• Country: United States
• Zip Code: 85721

Publications

Akam, E A; Utterback, R D; Marcero, J R et al. (2018) Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production. J Inorg Biochem 180:186-193

Hadinger, Kyle P; Marshalek, Joseph P; Sheeran, Paul S et al. (2018) Optimization of Phase-Change Contrast Agents for Targeting MDA-MB-231 Breast Cancer Cells. Ultrasound Med Biol 44:2728-2738

Han, Jiali; Li, Jianrong; Achour, Ikbel et al. (2018) Convergent downstream candidate mechanisms of independent intergenic polymorphisms between co-classified diseases implicate epistasis among noncoding elements. Pac Symp Biocomput 23:524-535

Galbraith, David W; Sliwinska, Elwira; Samadder, Partha (2018) Nuclear Cytometry: Analysis of the Patterns of DNA Synthesis and Transcription Using Flow Cytometry, Confocal Microscopy, and RNA Sequencing. Methods Mol Biol 1678:371-392

Nguyen, Mike M; Martinez, Jessica A; Hsu, Chiu-Hsieh et al. (2018) Bioactivity and prostate tissue distribution of metformin in a preprostatectomy prostate cancer cohort. Eur J Cancer Prev 27:557-562

Zeltzer, Sebastian; Zeltzer, Carol A; Igarashi, Suzu et al. (2018) Virus Control of Trafficking from Sorting Endosomes. MBio 9:

Kohler, Lindsay N; Harris, Robin B; Oren, Eyal et al. (2018) Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma. Nutrients 10:

Jones, Kyle M; Pagel, Mark D; Cárdenas-Rodríguez, Julio (2018) Linearization improves the repeatability of quantitative dynamic contrast-enhanced MRI. Magn Reson Imaging 47:16-24

Bea, Jennifer W; Funk, Janet; Hetherington-Rauth, Megan et al. (2018) Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls. Obesity (Silver Spring) 26:1594-1602

Hornbrook, Mark C; Cobb, Martha D; Tallman, Nancy J et al. (2018) Costs of an ostomy self-management training program for cancer survivors. Psychooncology 27:879-885