9.1.7 IMAGING CORE SHARED SERVICE The Cancer Center and affiliated programs house equipment and expertise in the development and application of a variety of in vivo imaging modilities including PET/SPECT, MR and optical approaches to in vivo imaging. The mission of the Imaging Core service is to provide Cancer Center members easy access to these state-of-the art in vivo imaging capabilities. Within this context, the Imaging Core provides three specific services to the Cancer Center members. An Institutional Imaging Advisory Committee provides a mechanism through which investigators may initiate projects, have them critically reviewed and facilitate access to appropriate image acquisition modalities. Optical imaging capabilities in confocal imaging, bioluminescence analysis of gene expression, and confocal endoscopy and spectroscopy are provided. The Core also provides access to technical expertise for operating and analyzing data acquired for pre-clinical MRI, PET/SPECT, and OCT, as well as. Clinical MRI approaches. A second area of focus, the Core is responsible for developing standardized platforms for image analysis housed in a centralized facility where experts in image processing and development of custom analysis algorithms are consolidated. The image processing facility, housed in the MRB, provides access to high end graphics computing capabilities, and experts who can provide both basic training and advice in image analysis approaches, as well as expertise to develop and customize specific image processing techniques. Thirdly, the Imaging Response Assessment Team (IRAT) has been incorporated into the ICSS for this renewal. The goal of this program is to increase the use of functional and molecular imaging endpoints as biomarkers in clinical drug trials. As such, all protocols initiated by AZCC investigators are vetted by the IRAT committee, who provide documented suggestions for inclusion of imaging endpoints. Consequently, the IRAT at AZCC will strictly conform to the ideals and concepts of the IRAT program and is committed to participating in the national consortium of IRATs focused on the use of quantitative imaging in clinical trials.

Public Health Relevance

The ICSS provides four specific services: (1) consultation on the development and application of imaging to projects within the AZCC;(2) access to, maintenance of, and expertise to operate specific image acquisition instruments;(3) access to sophisticated image analysis facilities and to expertise in image analysis and quantification, software development and operation, and (4) access to the IRAT.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023074-33
Application #
8279423
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
33
Fiscal Year
2011
Total Cost
$186,756
Indirect Cost
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Blohm-Mangone, Karen; Burkett, Nichole B; Tahsin, Shekha et al. (2018) Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice. Cancer Prev Res (Phila) 11:265-278
Tao, Shasha; Rojo de la Vega, Montserrat; Chapman, Eli et al. (2018) The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer. Mol Carcinog 57:182-192
Goldenberg, Joshua M; Pagel, Mark D; Cárdenas-Rodríguez, Julio (2018) Characterization of D-maltose as a T2 -exchange contrast agent for dynamic contrast-enhanced MRI. Magn Reson Med 80:1158-1164
Bell, Melanie L; Whitehead, Amy L; Julious, Steven A (2018) Guidance for using pilot studies to inform the design of intervention trials with continuous outcomes. Clin Epidemiol 10:153-157
Russ, Atlantis; Hua, Anh B; Montfort, William R et al. (2018) Blocking ""don't eat me"" signal of CD47-SIRP? in hematological malignancies, an in-depth review. Blood Rev 32:480-489
Berghout, Joanne; Li, Qike; Pouladi, Nima et al. (2018) Single subject transcriptome analysis to identify functionally signed gene set or pathway activity. Pac Symp Biocomput 23:400-411
Kannaiyan, Radhamani; Mahadevan, Daruka (2018) A comprehensive review of protein kinase inhibitors for cancer therapy. Expert Rev Anticancer Ther 18:1249-1270
Xie, Shuwei; Reinecke, James B; Farmer, Trey et al. (2018) Vesicular trafficking plays a role in centriole disengagement and duplication. Mol Biol Cell 29:2622-2631
Weinkauf, Craig C; Concha-Moore, Kirsten; Lindner, Jonathan R et al. (2018) Endothelial vascular cell adhesion molecule 1 is a marker for high-risk carotid plaques and target for ultrasound molecular imaging. J Vasc Surg 68:105S-113S
Song, Jin H; Singh, Neha; Luevano, Libia A et al. (2018) Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase. Mol Cancer Ther 17:2710-2721

Showing the most recent 10 out of 1336 publications