Analytical Chemistry Shared Resource (ACSR) The goal of Analytical Chemistry Shared Resource (ACSR), which was established in 2001, is to enhance the capabilities and productivity of University of Arizona Cancer Center investigators by providing a cutting-edge centralized Resource to perform analytical chemistry assays for small molecules (<1000 daltons) and pharmacokinetic and pharmacodynamic data analysis and interpretation. The ACSR has accumulated considerable expertise in quantitative analysis of small molecules, including drugs and exogenous and endogenous chemicals in biological specimens, using chromatography-mass spectrometry-based systems and in the development of analytical assay protocols tailored to the needs of UACC investigators. The ACSR provides the following services: 1) consultation on study design including selection of assays and / or development of new assays, coordination with activities of other Shared Resources, and data analysis; 2) development, validation and implementation of cancer-related bioanalytical assays; 3) performance of quantitative and qualitative analysis of cancer therapeutic and preventive agents, nutrients, carcinogens, endogenous biochemical, and imaging agents; 4) pharmacokinetic study design and PK and PD data analysis; 5) metabolomic profiling. During the current grant period, the ACSR has continued to build its repository of analytical assay protocols, many of which can be readily applied to new projects, and thus, the ACSR is able to support a broad spectrum of research projects in a cost-effective manner and with a rapid turnaround time. The leadership of the ACSR is responsive to research needs of the UACC investigators. In the current grant period, this has included the development and implementation of state-of-the-art metabolomic analyses. Services provided by the ACSR are essential for the assessment of drug/nutrient/carcinogen exposure and disposition, and for the measurement of endogenous biochemicals as surrogate cancer-risk biomarkers and endpoint biomarkers in intervention studies. These measurements are indispensable in many established lines of research at the UACC, including preclinical and clinical evaluation of cancer therapeutic drugs and preventive interventions, assessment of biological, environmental, and lifestyle factors associated with cancer risk and disease progression, and identification of potential targets for intervention.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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University of Arizona
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Lent, Adrienne B; O'Connor, Patrick A; Reikowsky, Ryan C et al. (2018) Quit outcomes among clients ineligible for cessation medication through the state quitline: a retrospective, observational study. BMC Public Health 18:1001
Bea, J W; Hsu, C-H; Blew, R M et al. (2018) Use of iDXA spine scans to evaluate total and visceral abdominal fat. Am J Hum Biol 30:
Zaim, Samir Rachid; Li, Qike; Schissler, A Grant et al. (2018) Emergence of pathway-level composite biomarkers from converging gene set signals of heterogeneous transcriptomic responses. Pac Symp Biocomput 23:484-495
Bulkley, Joanna E; McMullen, Carmit K; Grant, Marcia et al. (2018) Ongoing ostomy self-care challenges of long-term rectal cancer survivors. Support Care Cancer 26:3933-3939
Kelly, K R; Espitia, C M; Zhao, W et al. (2018) Oncolytic reovirus sensitizes multiple myeloma cells to anti-PD-L1 therapy. Leukemia 32:230-233
Kobes, Joseph E; Georgiev, George I; Louis, Anthony V et al. (2018) A Comparison of Iron Oxide Particles and Silica Particles for Tracking Organ Recellularization. Mol Imaging 17:1536012118787322
Sun, Virginia; Wendel, Christopher S; Demark-Wahnefried, Wendy et al. (2018) Diet and Behavior Modifications by Long-term Rectal Cancer Survivors to Manage Bowel Dysfunction-Associated Symptoms. Nutr Cancer :1-11
Downs, Charles A; Johnson, Nicholle M; Tsaprailis, George et al. (2018) RAGE-induced changes in the proteome of alveolar epithelial cells. J Proteomics 177:11-20
Mushtaq, Adeela; Kapoor, Vikas; Latif, Azka et al. (2018) Efficacy and toxicity profile of carfilzomib based regimens for treatment of multiple myeloma: A systematic review. Crit Rev Oncol Hematol 125:1-11
Rak, Michael A; Buehler, Jason; Zeltzer, Sebastian et al. (2018) Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency. J Virol 92:

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