The primary objective ofthe Cancer Prevention (CP) program is to use population science research methods to improve the knowledge base for promoting overall reductions in cancer incidence, mortality and morbidity. The CP program has 21 members from 11 academic departments. This group of investigators accomplishes its goals through effective integration of expertise in Family &Preventive Medicine, Psychiatry, Communication, Computer Science and Engineering, Pediatrics, Psychology, Surgery, Endocrinology, Reproductive Medicine, and Public Health. The program is organized in 3 major scientific themes as follows. Theme 1 is Cancer-Related Policy Research;Theme 2 is Diet, Obesity, and Cancer Risk;Theme 3 is Physical Activity Assessment and Interventions. In 2012, the CP program had $10.2 million of peer reviewed research grant funding (direct costs), including $4.1 million from NCI. Members ofthe CP program published 554 programmatically aligned articles since 2007;24% were the result of intra-programmatic collaborations and 20% were inter-programmatic. Significant scientific accomplishment include: (i) publication of the first report showing that nonsmoking policies have substantially reduced lung cancer rates in California and that this decline resulted from a decrease in the proportion of heavy smokers, (ii) the Women's Healthy Eating and Living (WHEL) study showed that maintenance of a low-fat diet high in vegetables, fruit, and fiber did not reduce recurrence or death in breast cancer survivors, and (iii) authorship of a landmark paper on built environment measures for physical activity. The program was active in 2012 with 1471 new patients in enrolled in intervention trials and 609 participants in observational studies. Proportions of participants by ethnic and racial categories approximate the MCC catchment area for adults aged 50 years and older (i.e., adults at risk of common-incidence cancers). The Cancer Center adds value to the research projects in CP by providing shared resource facilities, consultation on state of the art technologies, pilot project grants, opportunities for collaboration with other MCC programs, and recruitment of investigators.

Public Health Relevance

The primary objective ofthe Cancer Prevention (CP) program is to use population science research methods to improve the knowledge base for promoting overall reductions in cancer incidence, mortality and morbidity. The program focus areas include health behavior policy, studies of diet and obesity, and research in physical activity.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023100-28
Application #
8695642
Study Section
Subcommittee G - Education (NCI)
Project Start
1996-07-01
Project End
2019-04-30
Budget Start
2014-07-21
Budget End
2015-04-30
Support Year
28
Fiscal Year
2014
Total Cost
$26,399
Indirect Cost
$9,198
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Jiang, Qingfei; Jamieson, Catriona (2018) BET'ing on Dual JAK/BET Inhibition as a Therapeutic Strategy for Myeloproliferative Neoplasms. Cancer Cell 33:3-5
Ramirez, Oscar; Aristizabal, Paula; Zaidi, Alia et al. (2018) Implementing a Childhood Cancer Outcomes Surveillance System Within a Population-Based Cancer Registry. J Glob Oncol :1-11
Liu, Liang; Yang, Lin; Yan, Wei et al. (2018) Chemotherapy Induces Breast Cancer Stemness in Association with Dysregulated Monocytosis. Clin Cancer Res 24:2370-2382
Lwin, Thinzar M; Murakami, Takashi; Miyake, Kentaro et al. (2018) Tumor-Specific Labeling of Pancreatic Cancer Using a Humanized Anti-CEA Antibody Conjugated to a Near-Infrared Fluorophore. Ann Surg Oncol 25:1079-1085
Singh, Siddharth; Loomba, Rohit (2018) Role of two-dimensional shear wave elastography in the assessment of chronic liver diseases. Hepatology 67:13-15
Hartman, Sheri J; Nelson, Sandahl H; Myers, Emily et al. (2018) Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study. Cancer 124:192-202
Hoffmann, Hanne M; Gong, Ping; Tamrazian, Anika et al. (2018) Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol 461:143-154
Liu, Xuxiang; Cao, Minghui; Palomares, Melanie et al. (2018) Metastatic breast cancer cells overexpress and secrete miR-218 to regulate type I collagen deposition by osteoblasts. Breast Cancer Res 20:127
Huang, Justin K; Carlin, Daniel E; Yu, Michael Ku et al. (2018) Systematic Evaluation of Molecular Networks for Discovery of Disease Genes. Cell Syst 6:484-495.e5
Kalyanaraman, Hema; Schwaerzer, Gerburg; Ramdani, Ghania et al. (2018) Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes. Diabetes 67:607-623

Showing the most recent 10 out of 862 publications