The goal of the Reducing Cancer Disparities (RCD) Program is to develop and test the effectiveness of interventions to reduce cancer risk and modify behaviors among underserved populations in the MCC catchment area. This goal is accomplished through highly interactive teams of 18 faculty members from UCSD and SDSU that include expertise from the Departments of Family and Preventive Medicine, Surgery, and Psychiatry at UCSD, as well as the Graduate School of Public Health and Psychology Department at SDSU. RCD is organized into 3 thematic foci: Theme 1: Lifestyle factors in community-based studies;Theme 2: Tobacco cessation;Theme 3: Screening and early detection. In 2012, the Program had $9.1 million of peer reviewed research grant funding (annual direct costs), which includes $5.4 million from NCI. Members of RCD published 255 programmatically aligned articles since 2007;20% were the result of intraprogrammatic collaborations and 25% were inter-programmatic. Significant accomplishments in the last grant period include: (i) increased publication number;(ii) doubling of peer-reviewed funding;(iii) doubling of NCI funding;and (iv) increase in number of multi-investigational grants from 1 to 5, which includes the NCI funded U54 SDSU-UCSD Cancer Center Comprehensive Partnership grant. In 2012, RCD investigators enrolled 831 individuals in intervention trials and 20,574 in observational studies. Importantly, the representation of racial/ethnic minorities in intervention studies is very high, with Hispanic/Latinos making up the majority. The RCD Program is the major entity targeting cancer research directly relevant to underserved and racial/ethnic minority populations in the MCC catchment area. The Cancer Center adds value to the RCD Program by providing shared resource facilities, pilot project grants, and recruitment of outstanding investigators.

Public Health Relevance

The primary goal of the Reducing Cancer Disparities (RCD) Program is to develop and test the effectiveness of interventions to reduce cancer risk and modify behaviors among underserved populations in the MCC catchment area. RCD focuses on three specific areas: (i) lifestyle factors in community-based studies;(ii) tobacco cessation;and (iii) screening and early detection.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023100-28
Application #
8695648
Study Section
Subcommittee G - Education (NCI)
Project Start
1996-07-01
Project End
2019-04-30
Budget Start
2014-07-21
Budget End
2015-04-30
Support Year
28
Fiscal Year
2014
Total Cost
$24,734
Indirect Cost
$8,618
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Sagredo, Eduardo A; Blanco, Alejandro; Sagredo, Alfredo I et al. (2018) ADAR1-mediated RNA-editing of 3'UTRs in breast cancer. Biol Res 51:36
Ramdani, Ghania; Schall, Nadine; Kalyanaraman, Hema et al. (2018) cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss. J Endocrinol 238:203-219
Nguyen, Vi; Marmor, Rebecca A; Ramamoorthy, Sonia L et al. (2018) The Use of Solicited Publishing by Academic Surgeons. Surgery 164:212-218
Yan, Wei; Wu, Xiwei; Zhou, Weiying et al. (2018) Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol 20:597-609
Pandolfi, Erica C; Hoffmann, Hanne M; Schoeller, Erica L et al. (2018) Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol 55:8709-8727
Galanina, Natalie; Goodman, Aaron M; Cohen, Philip R et al. (2018) Successful Treatment of HIV-Associated Kaposi Sarcoma with Immune Checkpoint Blockade. Cancer Immunol Res 6:1129-1135
Chin, Andrew R; Yan, Wei; Cao, Minghui et al. (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia. J Mammary Gland Biol Neoplasia 23:165-176
Garcia, Daniel A; Baek, Christina; Estrada, M Valeria et al. (2018) USP11 Enhances TGF?-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis. Mol Cancer Res 16:1172-1184
Jiang, Qingfei; Jamieson, Catriona (2018) BET'ing on Dual JAK/BET Inhibition as a Therapeutic Strategy for Myeloproliferative Neoplasms. Cancer Cell 33:3-5
Ramirez, Oscar; Aristizabal, Paula; Zaidi, Alia et al. (2018) Implementing a Childhood Cancer Outcomes Surveillance System Within a Population-Based Cancer Registry. J Glob Oncol :1-11

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