CANCER CONTROL PROGRAM ABSTRACT The mission of the Cancer Control Program (CCP) is to reduce the burden of cancer from prevention to survivorship.
Specific Aims are: (1) to prevent tobacco-related cancers by reducing the prevalence of tobacco product use, (2) to prevent obesity-related cancers through lifestyle and community intervention approaches, (3) to interrupt the development of cancer through screening, early detection, and testing interventions in premalignant neoplasia, and (4) to enhance the quality and length of survival of persons diagnosed with cancer through treatment and intervention. CCP addresses the catchment area by conducting studies in underserved populations including Hispanics, older adults, and low-income populations; and its research on locally prevalent cancers. CCP research includes extensive use of technology in the objective assessment of cancer risk factors and the delivery of lifestyle interventions. In 2017, Kerr (UC San Diego) and Elder (San Diego State University (SDSU)) were appointed Co-Leaders of the CCP. They are internationally recognized scientists who share a commitment to mentoring and catchment-based research, while bringing complementary expertise in disparities (Elder) and technology (Kerr). Through resources, organization, and leadership support for the CCP, Moores Cancer Center (MCC) provides a valuable platform for population scientists that results in collaborative scientific accomplishments and makes an impact on reducing the cancer burden in the MCC catchment area. CCP includes 36 members, of which 80% are PIs of peer-reviewed grants. CCP is highly transdisciplinary and includes 28 population scientists (biostatisticians, behavioral scientists, epidemiologists, economists, geographers), 7 clinicians, and 1 basic scientist. Twenty-eight percent of members are faculty at SDSU, an MCC consortium partner. In 2017, program members had $8.4 Million in cancer focused, peer-reviewed funding (direct costs), of which $2.4 Million (29%) was from NCI, $4.2 Million (51%) was from other NIH sources, and $1.7 Million (20%) was from other peer-reviewing agencies. During the project period, members authored 985 cancer-relevant publications, of which 245 (25%) were intra-programmatic, 170 (17%) were inter-programmatic, and 383 (39%) were collaborative with investigators in other NCI-designated cancer centers. Accruals in 2017 were 461 in interventional studies and 660 in non-interventional studies. CCP members play key roles in the educational and training activities described in the Cancer-Related Career Enhancement and Related Activities resource. Future plans include expanding CCP expertise in dissemination and implementation science to collaborate with other program members and translate findings into practice, harnessing CCP expertise in technology to expand the reach of intervention recruitment and delivery to the catchment area and developing joint activities to foster the development of collaborative and clinical efforts in cancer detection and prevention.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023100-34
Application #
9936332
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
34
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Jiang, Qingfei; Jamieson, Catriona (2018) BET'ing on Dual JAK/BET Inhibition as a Therapeutic Strategy for Myeloproliferative Neoplasms. Cancer Cell 33:3-5
Ramirez, Oscar; Aristizabal, Paula; Zaidi, Alia et al. (2018) Implementing a Childhood Cancer Outcomes Surveillance System Within a Population-Based Cancer Registry. J Glob Oncol :1-11
Liu, Liang; Yang, Lin; Yan, Wei et al. (2018) Chemotherapy Induces Breast Cancer Stemness in Association with Dysregulated Monocytosis. Clin Cancer Res 24:2370-2382
Lwin, Thinzar M; Murakami, Takashi; Miyake, Kentaro et al. (2018) Tumor-Specific Labeling of Pancreatic Cancer Using a Humanized Anti-CEA Antibody Conjugated to a Near-Infrared Fluorophore. Ann Surg Oncol 25:1079-1085
Singh, Siddharth; Loomba, Rohit (2018) Role of two-dimensional shear wave elastography in the assessment of chronic liver diseases. Hepatology 67:13-15
Hartman, Sheri J; Nelson, Sandahl H; Myers, Emily et al. (2018) Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study. Cancer 124:192-202
Hoffmann, Hanne M; Gong, Ping; Tamrazian, Anika et al. (2018) Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol 461:143-154
Liu, Xuxiang; Cao, Minghui; Palomares, Melanie et al. (2018) Metastatic breast cancer cells overexpress and secrete miR-218 to regulate type I collagen deposition by osteoblasts. Breast Cancer Res 20:127
Huang, Justin K; Carlin, Daniel E; Yu, Michael Ku et al. (2018) Systematic Evaluation of Molecular Networks for Discovery of Disease Genes. Cell Syst 6:484-495.e5
Kalyanaraman, Hema; Schwaerzer, Gerburg; Ramdani, Ghania et al. (2018) Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes. Diabetes 67:607-623

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