This is a request for continuation of NCI recognition of comprehensive status and of Cancer Center Support Grant funding for the Norris Cotton Cancer Center (NCCC) at Dartmouth-Hitchcock Medical Center (DHMC). NCCC is a matrix-type cancer center, organized as an interdepartmental component of DHMC, with overall responsibility for cancer research, cancer care, and educational and service activities in cancer. Our request is for five years (Years 26-30) of funding for the core infrastructure that supports cancer research at NCCC. The 131 scientists of the NCCC are organized into six Research Programs: Cancer Control; Cancer Epidemiology and Chemoprevention; Cancer Mechanisms; Molecular Therapeutics; Immunology and Cancer Immunotherapy; and Radiobiology and Bioengineering. Each of these Research Programs integrates peer-reviewed funded cancer researchers from a variety of basic science and clinical or population science disciplines. The research efforts of these Programs receive support through NCCC Shared Resources in Behavioral Science, Bioinformatics, Flow Cytometry/Fluorescence Imaging, Glassware Washing, Hybridoma Library/Monoclonal Antibody Production, Immune Monitoring Laboratory, Irradiation, Microarray, Molecular Biology and Proteomics, Transgenic Mouse, Biostatistics, Clinical and Molecular Pharmacology, Research Pathology Services, and Clinical Research Office. The NCCC provides developmental funds to support innovative, collaborative pilot projects; new shared resources; and the initial research efforts of new investigators. We request support for these developmental efforts and for leadership, administrative, shared resource and planning activities that are crucial to the maintenance of a coordinated and interactive program in cancer research.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ciolino, Henry P
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dartmouth College
Schools of Medicine
United States
Zip Code
Barr, Fiona D; Ochsenbauer, Christina; Wira, Charles R et al. (2018) Neutrophil extracellular traps prevent HIV infection in the female genital tract. Mucosal Immunol 11:1420-1428
Jackson, Brian P (2018) Low level determination of gallium isotopes by ICP-QQQ. J Anal At Spectrom 33:897-900
Rahme, Gilbert J; Luikart, Bryan W; Cheng, Chao et al. (2018) A recombinant lentiviral PDGF-driven mouse model of proneural glioblastoma. Neuro Oncol 20:332-342
Wang, Zhaoxi; Wei, Yongyue; Zhang, Ruyang et al. (2018) Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma. EBioMedicine 32:93-101
Sergent, P A; Plummer, S F; Pettus, J et al. (2018) Blocking the VISTA pathway enhances disease progression in (NZB?×?NZW) F1 female mice. Lupus 27:210-216
Kachuri, Linda; Saarela, Olli; Bojesen, Stig Egil et al. (2018) Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers. Int J Epidemiol :
Rodriguez-Garcia, Marta; Fortier, Jared M; Barr, Fiona D et al. (2018) Aging impacts CD103+ CD8+ T cell presence and induction by dendritic cells in the genital tract. Aging Cell 17:e12733
Shajani-Yi, Zahra; de Abreu, Francine B; Peterson, Jason D et al. (2018) Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing. Neoplasia 20:256-262
Shee, Kevin; Jiang, Amanda; Varn, Frederick S et al. (2018) Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer. FASEB J :fj201801241R
Bossé, Yohan; Amos, Christopher I (2018) A Decade of GWAS Results in Lung Cancer. Cancer Epidemiol Biomarkers Prev 27:363-379

Showing the most recent 10 out of 1911 publications