Abstract

The Microarray Shared Resource provides technologies to NCCC and Dartmouth community investigators that enable profiling of gene expression on a whole-genome scale. The Resource also enables whole-genome surveys of genetic variations known as single nucleotide polymorphisms (SNPs). The Resource will synergize with the Bioinformatics Shared Resource to enhance genomics and bioinformatics capabilities within our research community. The Shared Resource presently has an Affymetrix GeneChip Workstation in operation, and is adding an Agilent SureScan scanner and microarray system. The Affymetrix Workstation is a thoroughly proven system for high quality but low throughput gene expression and SNP analyses. The Agilent system will offer enhanced throughput capabilities more compatible with large sample numbers coming from clinical trials. The Resource also provides capabilities for quantitative real-time PCR so that investigators can validate observations made on the microarrays. The long-term goal of the Microarray Shared Resource is to provide an efficient and affordable fee-for-service operation that will provide high-quality microarray data for the growing number of NCCC investigators who require this service.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023108-30
Application #
7586075
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2007-12-01
Budget End
2008-11-30
Support Year
30
Fiscal Year
2008
Total Cost
$128,985
Indirect Cost

  Institution

Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755

  Publications

Courtney, Andrea L; Rapuano, Kristina M; Sargent, James D et al. (2018) Reward System Activation in Response to Alcohol Advertisements Predicts College Drinking. J Stud Alcohol Drugs 79:29-38
Geller, Berta M; Frederick, Paul D; Knezevich, Stevan R et al. (2018) Pathologists' Use of Second Opinions in Interpretation of Melanocytic Cutaneous Lesions: Policies, Practices, and Perceptions. Dermatol Surg 44:177-185
Yeager, Mark P; Guyre, Cheryl A; Sites, Brian D et al. (2018) The Stress Hormone Cortisol Enhances Interferon-?-Mediated Proinflammatory Responses of Human Immune Cells. Anesth Analg 127:556-563
Rodriguez-Garcia, Marta; Fortier, Jared M; Barr, Fiona D et al. (2018) Isolation of Dendritic Cells from the Human Female Reproductive Tract for Phenotypical and Functional Studies. J Vis Exp :
Aschbrenner, Kelly A; Bobak, Carly; Schneider, Emily J et al. (2018) Egocentric social networks and smoking among adults with serious mental illness. Transl Behav Med 8:531-539
Tapp, Stephanie J; Martin, Brook I; Tosteson, Tor D et al. (2018) Understanding the value of minimally invasive procedures for the treatment of lumbar spinal stenosis: the case of interspinous spacer devices. Spine J 18:584-592
Kuklinski, Lawrence F; Yan, Shaofeng; Li, Zhongze et al. (2018) VISTA expression on tumor-infiltrating inflammatory cells in primary cutaneous melanoma correlates with poor disease-specific survival. Cancer Immunol Immunother 67:1113-1121
Shee, Kevin; Yang, Wei; Hinds, John W et al. (2018) Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer. J Exp Med 215:895-910
Gareen, Ilana F; Black, William C; Tosteson, Tor D et al. (2018) Medical Care Costs Were Similar Across the Low-dose Computed Tomography and Chest X-Ray Arms of the National Lung Screening Trial Despite Different Rates of Significant Incidental Findings. Med Care 56:403-409
Miles, Randy; Wan, Fei; Onega, Tracy L et al. (2018) Underutilization of Supplemental Magnetic Resonance Imaging Screening Among Patients at High Breast Cancer Risk. J Womens Health (Larchmt) 27:748-754

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