The Mass Spectrometry Shared Resource provides critical services to Cancer Center members whose research relies on structure determination of a variety of different molecules. Services currently provided by the Shared Resource include high and low resolution fast atom bombardment (FAB) ionization, high and low resolution electron ionization (El), and high and low resolution chemical ionization (CI). After the installation of. two new instruments, mass spectrometry services will be expanded to include high and low resolution electrospray ionization (ESl), tandem mass spectrometry (MSIMS), and LC-MS capabilities. Except for low resolution El and CI analyses, the Shared Resource is the only location at Purdue University where the above mass spectrometry techniques can be performed. This facility is overwhelmingly utilized for cancer-related research and derives considerable benefit from its participation in the Campus-Wide Mass Spectrometry Center (CWMSC), which insures service to the entire cancer research community at Purdue University. The Mass Spectrometry Shared Resource, in conjunction with the CWMSC, has several goals including: I) coordinating the operation and maintenance of mass spectrometers used for routine analyses, 2) providing research groups working on cancer related problems with access to all of the mass spectrometry technology on campus, 3) increasing awareness of the opportunities for problem solving by mass spectrometry, 4) coordinating the acquisition of new instrumentation as needs arise, and 5) developing new methods required to analyze user samples. Cancer Center members derive considerable benefit from the instrumentation and expertise provided by this Shared Resource and its personnel.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023168-23
Application #
6469210
Study Section
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
23
Fiscal Year
2001
Total Cost
$216,966
Indirect Cost
Name
Purdue University
Department
Type
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Lee, Hyeon Jeong; Li, Jie; Vickman, Renee E et al. (2018) Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway. Mol Cancer Res 16:974-985
Bhandari, Pushpak; Novikova, Gloriia; Goergen, Craig J et al. (2018) Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep 8:3112
Dhawan, Deepika; Hahn, Noah M; Ramos-Vara, José A et al. (2018) Naturally-occurring canine invasive urothelial carcinoma harbors luminal and basal transcriptional subtypes found in human muscle invasive bladder cancer. PLoS Genet 14:e1007571
Shinde, Aparna; Libring, Sarah; Alpsoy, Aktan et al. (2018) Autocrine Fibronectin Inhibits Breast Cancer Metastasis. Mol Cancer Res 16:1579-1589
Ghosh, Arun K; Ghosh, Koena; Brindisi, Margherita et al. (2018) Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorg Med Chem Lett 28:2605-2610
Thompson, Taylor J; Han, Bumsoo (2018) Analysis of adhesion kinetics of cancer cells on inflamed endothelium using a microfluidic platform. Biomicrofluidics 12:042215
Alpsoy, Aktan; Dykhuizen, Emily C (2018) Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem 293:3892-3903
Larocque, Elizabeth A; Naganna, N; Opoku-Temeng, Clement et al. (2018) Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase. ChemMedChem 13:1172-1180
Kumari, Rashmi; Silic, Martin R; Jones-Hall, Yava L et al. (2018) Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors. Oncotarget 9:23494-23504
VerHeul, Ross; Sweet, Craig; Thompson, David H (2018) Rapid and simple purification of elastin-like polypeptides directly from whole cells and cell lysates by organic solvent extraction. Biomater Sci 6:863-876

Showing the most recent 10 out of 436 publications