The Purdue University Center for Cancer Research (PCCR) was established as an NCI basic science cancer center in 1978. As such, the PCCR's mission focuses on basic discovery - discovery that is the foundation through which the PCCR fosters innovative cancer solutions. Notably, the PCCR not only supports basic discovery but also facilitates discovery application and, where possible, positions discoveries for transfer to the public domain. Purdue strengths in engineering, veterinary medicine, nutrition science, chemistry, medicinal chemistry, pharmacy, structural biology, and biological sciences, form the core foundation upon which the PCCR facilitates discovery centered on understanding the biology of the cancer cell, developing innovative technology to probe cancer-related phenomena, creating diagnostic and imaging tools, and synthesizing unique therapeutic chemical entities that can be delivered to the cancer cell by novel technology. To facilitate the mission of discovery, the PCCR has established a transdisciplinary environment that focuses PCCR core strengths on providing novel solutions to cancer problems. As a matrix center, PCCR leadership draws on core capabilities through its 97 members from 18 academic departments and 6 colleges across Purdue, to organize an infrastructure based on four Research Programs: Chemical and Structural Biology (CSB), Cell Identity and Signaling (CIS), Medicinal Chemistry (MC), and Drug Delivery and Molecular Sensing (DDMS). The PCCR expedites discovery through management of 7 Shared Resources (Flow Cytometry and Cell Separation (FC-SR), DNA Sequencing (SEQ-SR), Macromolecular Crystallography (MM-SR), Mass Spectrometry (MS-SR), Nuclear Magnetic Resonance (NMR-SR), Biological Evaluation (BE-SR) and Transgenic Mouse (TMCF-SR)) which provide researchers access to state-of-the-art expertise to analyze cells, nucleic acids and proteins, to determine detailed molecular structures that can be used to design drugs, to evaluate targets/drugs in vivo, and to develop new animal models of cancer. The PCCR fosters a remarkable breadth of cancer research spanning clinical evaluations of dogs with spontaneous malignancies as an evaluative process in drug development and validation of targets and technologies, to probing the fundamentals of molecular motion through interferometry and determining its application for innovative cancer solutions, and the application of the pioneering technology that is based on ionizing molecules in ambient conditions for mass spectrometry analysis to identify cancer markers and which opened doors for additional technological assessments and mechanistic biological studies. Finally, the PCCR maintains the Essential Characteristics for a Cancer Center including exceptional Physical Space, effective Organizational Capabilities that provide the foundation for innovative cancer research, a Transdisciplinary Collaborative environment that facilitates fundamental discovery with a Cancer Focus, exceptional Institutional Commitment to expand and enhance cancer research at Purdue, and outstanding Center Director leadership that drives the development of cancer solutions.

Public Health Relevance

Overall Component: Project Narrative As a basic science cancer center, the PCCR, through its fundamental research effort, serves its state, country and the world through innovative discovery and its application to cancer solutions. Through drug discovery, drug delivery, imaging technology and biomarker discovery, the PCCR applies innovative solutions to major cancer problems.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023168-36
Application #
9108253
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Ptak, Krzysztof
Project Start
1997-04-01
Project End
2020-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
36
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
Organized Research Units
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Rangasamy, Loganathan; Chelvam, Venkatesh; Kanduluru, Ananda Kumar et al. (2018) New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange. Bioconjug Chem 29:1047-1059
Zhang, Hao; Zhang, Yanqiu; Zhu, Xiaoyun et al. (2018) DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1. Hepatology :
Lee, Hyeon Jeong; Li, Jie; Vickman, Renee E et al. (2018) Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway. Mol Cancer Res 16:974-985
Bhandari, Pushpak; Novikova, Gloriia; Goergen, Craig J et al. (2018) Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep 8:3112
Dhawan, Deepika; Hahn, Noah M; Ramos-Vara, José A et al. (2018) Naturally-occurring canine invasive urothelial carcinoma harbors luminal and basal transcriptional subtypes found in human muscle invasive bladder cancer. PLoS Genet 14:e1007571
Shinde, Aparna; Libring, Sarah; Alpsoy, Aktan et al. (2018) Autocrine Fibronectin Inhibits Breast Cancer Metastasis. Mol Cancer Res 16:1579-1589
Ghosh, Arun K; Ghosh, Koena; Brindisi, Margherita et al. (2018) Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorg Med Chem Lett 28:2605-2610
Thompson, Taylor J; Han, Bumsoo (2018) Analysis of adhesion kinetics of cancer cells on inflamed endothelium using a microfluidic platform. Biomicrofluidics 12:042215
Alpsoy, Aktan; Dykhuizen, Emily C (2018) Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem 293:3892-3903
Larocque, Elizabeth A; Naganna, N; Opoku-Temeng, Clement et al. (2018) Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase. ChemMedChem 13:1172-1180

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