Abstract

Biomolecular Structure Shared Resource (BS-SR): Project Summary Determination of macromolecular structures and their complexes with small molecule drugs by X-ray crystallography, cryo-electron microscopy, and NMR spectroscopy is paramount to understanding biological processes and disease at the molecular level and to the rational design of highly selective therapeutic agents. Accordingly, the primary mission of the Biomolecular Structure Shared Resource (BS-SR) is to provide Purdue University Center for Cancer Research (PCCR) members with facilitated access to state-of-the-art technologies, hardware and expertise across a wide range of structural biology modalities that will allow them to investigate cancer mechanisms and to perform iterative, structure-based design of anti-cancer therapeutics. By providing PCCR members with services and instrument time at a lower cost, PCCR members can also more efficiently use their research funds, further enhancing their competitiveness in obtaining peer-reviewed funding.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023168-40
Application #
10024908
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-08-01
Budget End
2021-06-30
Support Year
40
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Type
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Huang, Xinxin; Guo, Bin; Liu, Sheng et al. (2018) Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment. Nat Commun 9:2741
Chambers, Andrea M; Lupo, Kyle B; Matosevic, Sandro (2018) Tumor Microenvironment-Induced Immunometabolic Reprogramming of Natural Killer Cells. Front Immunol 9:2517
Shinde, Aparna; Wilmanski, Tomasz; Chen, Hao et al. (2018) Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer. Breast Cancer Res 20:76
Nenortas, Nathaniel P; Cinelli, Maris A; Morrell, Andrew E et al. (2018) Activity of Aromathecins against African Trypanosomes. Antimicrob Agents Chemother 62:
Norvil, Allison B; Petell, Christopher J; Alabdi, Lama et al. (2018) Dnmt3b Methylates DNA by a Noncooperative Mechanism, and Its Activity Is Unaffected by Manipulations at the Predicted Dimer Interface. Biochemistry 57:4312-4324
Chambers, Andrea M; Wang, Jiao; Lupo, Kyle B et al. (2018) Adenosinergic Signaling Alters Natural Killer Cell Functional Responses. Front Immunol 9:2533
Serratore, Nina D; Baker, Kortany M; Macadlo, Lauren A et al. (2018) A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression in Saccharomyces cerevisiae. Genetics 208:1037-1055
Wu, Heng; Post, Carol Beth (2018) Protein Conformational Transitions from All-Atom Adaptively Biased Path Optimization. J Chem Theory Comput 14:5372-5382
Denton, Kyle E; Wang, Sijie; Gignac, Michael C et al. (2018) Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8. SLAS Discov 23:417-428
Liu, Wenting; Zhong, Yi-Fang; Liu, Liu-Yi et al. (2018) Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding. Nat Commun 9:3496

Showing the most recent 10 out of 436 publications