Cancer Control and Population Sciences Program ABSTRACT The mission of the Cancer Control and Population Sciences (CCPS) Program is to advance the science and application of cancer etiology, prevention, and outcomes research. The goal is to reduce the burden of cancer and its sequelae across all segments of the population through collaborative, multidisciplinary efforts. To achieve this goal, the Program has three themes: 1) To discover host and environmental factors contributing to cancer; 2) To identify factors to reduce health-related morbidity and mortality from cancer treatment; and 3) To develop, implement and evaluate interventions to reduce cancer-related morbidity/mortality and improve quality of life (QOL). Within each of these themes, research is on-going to reduce health disparities within our catchment area. As importantly, each theme encompasses strong education components ranging from K-12 programs in the community to healthcare provider and caregiver training for better communication and care for cancer survivors. Targeted recruits with national prominence add both depth and breadth to the Program and include Drs. Seewaldt, Chlebowski, Gray, Kittles, and Yee. The CCPS Program is particularly invested in the following key areas: building a robust portfolio of research in cancer etiology and biomarker development; strengthening the focus on understanding risk factors for treatment-related complications and developing tailored interventions to reduce morbidity in cancer survivors; recognizing causes of disparities in outcome unique to disease type and developing tailored interventions to systematically mitigate the disparities; and continuing to build upon the strong portfolio of research in psychosocial outcomes and tailored interventions to improve QOL. Sponsored activities include monthly work in progress meetings, monthly seminars, an annual retreat, and annual pilot funding. Membership: 23 Program Members representing 4 basic and clinical departments Publications: 410 total. 34.6% intra-programmatic; 20.2% inter-programmatic; 58.0% inter-institutional Funding: $7,770,700 peer-reviewed; $5,788,708 of which is NCI funding

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA033572-38
Application #
10059210
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Roberson, Sonya
Project Start
1997-08-01
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
38
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Beckman Research Institute/City of Hope
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Raz, Dan J; Wu, Geena X; Consunji, Martin et al. (2018) The Effect of Primary Care Physician Knowledge of Lung Cancer Screening Guidelines on Perceptions and Utilization of Low-Dose Computed Tomography. Clin Lung Cancer 19:51-57
Solomon, Ilana; Rybak, Christina; Van Tongeren, Lily et al. (2018) Experience Gained from the Development and Execution of a Multidisciplinary Multi-syndrome Hereditary Colon Cancer Family Conference. J Cancer Educ :
Tirughana, Revathiswari; Metz, Marianne Z; Li, Zhongqi et al. (2018) GMP Production and Scale-Up of Adherent Neural Stem Cells with a Quantum Cell Expansion System. Mol Ther Methods Clin Dev 10:48-56
Cheng, Chun-Ting; Qi, Yue; Wang, Yi-Chang et al. (2018) Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction. Commun Biol 1:178
Cho, H; Ayers, K; DePills, L et al. (2018) Modelling acute myeloid leukaemia in a continuum of differentiation states. Lett Biomath 5:S69-S98
Wang, Dongrui; Aguilar, Brenda; Starr, Renate et al. (2018) Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity. JCI Insight 3:
Liu, Xuxiang; Cao, Minghui; Palomares, Melanie et al. (2018) Metastatic breast cancer cells overexpress and secrete miR-218 to regulate type I collagen deposition by osteoblasts. Breast Cancer Res 20:127
Das, Sadhan; Reddy, Marpadga A; Senapati, Parijat et al. (2018) Diabetes Mellitus-Induced Long Noncoding RNA Dnm3os Regulates Macrophage Functions and Inflammation via Nuclear Mechanisms. Arterioscler Thromb Vasc Biol 38:1806-1820
Querfeld, Christiane; Leung, Samantha; Myskowski, Patricia L et al. (2018) Primary T Cells from Cutaneous T-cell Lymphoma Skin Explants Display an Exhausted Immune Checkpoint Profile. Cancer Immunol Res 6:900-909
Petrossian, Karineh; Kanaya, Noriko; Lo, Chiao et al. (2018) ER?-mediated cell cycle progression is an important requisite for CDK4/6 inhibitor response in HR+ breast cancer. Oncotarget 9:27736-27751

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