Cancer Control and Population Sciences Program ABSTRACT The mission of the Cancer Control and Population Sciences (CCPS) Program is to advance the science and application of cancer etiology, prevention, and outcomes research. The goal is to reduce the burden of cancer and its sequelae across all segments of the population through collaborative, multidisciplinary efforts. To achieve this goal, the Program has three themes: 1) To discover host and environmental factors contributing to cancer; 2) To identify factors to reduce health-related morbidity and mortality from cancer treatment; and 3) To develop, implement and evaluate interventions to reduce cancer-related morbidity/mortality and improve quality of life (QOL). Within each of these themes, research is on-going to reduce health disparities within our catchment area. As importantly, each theme encompasses strong education components ranging from K-12 programs in the community to healthcare provider and caregiver training for better communication and care for cancer survivors. Targeted recruits with national prominence add both depth and breadth to the Program and include Drs. Seewaldt, Chlebowski, Gray, Kittles, and Yee. The CCPS Program is particularly invested in the following key areas: building a robust portfolio of research in cancer etiology and biomarker development; strengthening the focus on understanding risk factors for treatment-related complications and developing tailored interventions to reduce morbidity in cancer survivors; recognizing causes of disparities in outcome unique to disease type and developing tailored interventions to systematically mitigate the disparities; and continuing to build upon the strong portfolio of research in psychosocial outcomes and tailored interventions to improve QOL. Sponsored activities include monthly work in progress meetings, monthly seminars, an annual retreat, and annual pilot funding. Membership: 23 Program Members representing 4 basic and clinical departments Publications: 410 total. 34.6% intra-programmatic; 20.2% inter-programmatic; 58.0% inter-institutional Funding: $7,770,700 peer-reviewed; $5,788,708 of which is NCI funding

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA033572-38
Application #
10059210
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Roberson, Sonya
Project Start
1997-08-01
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
38
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Beckman Research Institute/City of Hope
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Tobin, Steven J; Wakefield, Devin L; Jones, Veronica et al. (2018) Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2. Sci Rep 8:15154
Smith, Laura J; Wright, Jason; Clark, Gabriella et al. (2018) Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing. Proc Natl Acad Sci U S A 115:E7379-E7388
Leung, Amy; Trac, Candi; Kato, Hiroyuki et al. (2018) LTRs activated by Epstein-Barr virus-induced transformation of B cells alter the transcriptome. Genome Res 28:1791-1798
Li, Li; Tian, E; Chen, Xianwei et al. (2018) GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease. Cell Stem Cell 23:239-251.e6
Chin, Andrew R; Yan, Wei; Cao, Minghui et al. (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia. J Mammary Gland Biol Neoplasia 23:165-176
Pal, Sumanta K; He, Miaoling; Chen, Lin et al. (2018) Synaptophysin expression on circulating tumor cells in patients with castration resistant prostate cancer undergoing treatment with abiraterone acetate or enzalutamide. Urol Oncol 36:162.e1-162.e6
Romsdahl, Jillian; Blachowicz, Adriana; Chiang, Abby J et al. (2018) Characterization of Aspergillus niger Isolated from the International Space Station. mSystems 3:
Gong, Jun; Salgia, Ravi (2018) Managing Patients With Relapsed Small-Cell Lung Cancer. J Oncol Pract 14:359-366
Chen, Robert W; Palmer, Joycelynne M; Tomassetti, Sarah et al. (2018) Multi-center phase II trial of bortezomib and rituximab maintenance combination therapy in patients with mantle cell lymphoma after consolidative autologous stem cell transplantation. J Hematol Oncol 11:87
Gu, Long; Lingeman, Robert; Yakushijin, Fumiko et al. (2018) The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res 24:6053-6065

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