Abstract

Clinical Protocol and Data Management (CPDM) ABSTRACT The City of Hope Comprehensive Cancer Center (COHCCC) CPDM provides a centralized, comprehensive infrastructure which supports the conduct of all translational and clinical research. The CPDM encompasses two divisions: (1) Clinical Research Operations and (2) Clinical Research Informatics. The CPDM is led by Dr. Larry Kwak, MD, PhD, Associate Director for Experimental Therapeutic and Translational Research. Clinical Research Operations is led by Ashley Baker Lee, Senior Vice President for Research Operations and is responsible for study activation, education and training, policy and procedure development as well as accruals, data management and quality, and data and safety monitoring. Informatics, which includes Clinical Research Informatics, is led by Sorena Nadaf, Senior Vice President and Chief Informatics Officer and continues to provide support for the centralized systems which house COHCCC protocols (CTOL), clinical trials management system (MIDAS) and case report form development (Medidata Rave). The CPDM provides a strong foundation for high-quality clinical research by ensuring quality design of COH initiated research, efficient study start up, accurate collection of data to meet protocol objectives, protocol compliance and monitoring trial conduct and progress. As a centralized and integrated resource, CPDM provides dedicated and experienced staff to support COH?s robust and growing research portfolio.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA033572-38
Application #
10059215
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Roberson, Sonya
Project Start
1997-08-01
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
38
Fiscal Year
2021
Total Cost
Indirect Cost

  Institution

Name
Beckman Research Institute/City of Hope
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010

  Publications

Gong, Jun; Salgia, Ravi (2018) Managing Patients With Relapsed Small-Cell Lung Cancer. J Oncol Pract 14:359-366
Chen, Robert W; Palmer, Joycelynne M; Tomassetti, Sarah et al. (2018) Multi-center phase II trial of bortezomib and rituximab maintenance combination therapy in patients with mantle cell lymphoma after consolidative autologous stem cell transplantation. J Hematol Oncol 11:87
Romsdahl, Jillian; Blachowicz, Adriana; Chiang, Abby J et al. (2018) Characterization of Aspergillus niger Isolated from the International Space Station. mSystems 3:
Sen, Subha; He, Zhiheng; Ghosh, Shubhamoy et al. (2018) PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5. J Immunol 201:440-450
Lueschow, Shiloh R; Stumphy, Jessica; Gong, Huiyu et al. (2018) Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis. PLoS One 13:e0204967
Gu, Long; Lingeman, Robert; Yakushijin, Fumiko et al. (2018) The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res 24:6053-6065
Zhao, Xingli; Zhang, Zhuoran; Moreira, Dayson et al. (2018) B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors. Mol Ther 26:695-707
Weitzel, Jeffrey N; Chao, Elizabeth C; Nehoray, Bita et al. (2018) Somatic TP53 variants frequently confound germ-line testing results. Genet Med 20:809-816
Ghose, Jayeeta; Viola, Domenico; Terrazas, Cesar et al. (2018) Daratumumab induces CD38 internalization and impairs myeloma cell adhesion. Oncoimmunology 7:e1486948
Aslamy, Arianne; Oh, Eunjin; Olson, Erika M et al. (2018) Doc2b Protects ?-Cells Against Inflammatory Damage and Enhances Function. Diabetes 67:1332-1344

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