Abstract

The Jackson Laboratory (TJL) was founded in 1929 by Dr. Clarence Cook Little as a mammalian genetics research center focusing on the problem of cancer. The long term goal of TJL Cancer Center program is to contribute to basic understanding of the genetic determinants of cancer. Expertise in the genetics and biology of the laboratory mouse is the predominant strength of TJL Cancer Center and is the centerpiece of the cancer research conducted here. The mouse represents a powerful mammalian model for human genetic organization and regulation, modes of inheritance, and disease. Researchers are identifying sets of associated genes participating in complex diseases and beginning to elucidate their modes of interaction. Epigenetic factors influencing gene action, mutagenesis, and cancer risk are being isolated and identified. Other investigators are discovering the molecular regulation of developmental processes, the dysregulation of which can lead to cellular transformation. A wide array of inbred, congenic, and mutant strains of mice are available for investigations into the control of immune functions and development of immunotherapies for cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA034196-16
Application #
2748695
Study Section
Cancer Centers and Research Programs Review Committee (CCRP)
Program Officer
Vembu, Devi
Project Start
1996-08-25
Project End
2001-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
16
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Sharma, Manju; Braun, Robert E (2018) Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis. Development 145:
Shi, Jiayuan; Hua, Li; Harmer, Danielle et al. (2018) Cre Driver Mice Targeting Macrophages. Methods Mol Biol 1784:263-275
Hosur, Vishnu; Farley, Michelle L; Low, Benjamin E et al. (2018) RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models? Front Genet 9:233
Johnson, Kenneth R; Gagnon, Leona H; Tian, Cong et al. (2018) Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice. Genetics 208:1165-1179
Dominguez, Pilar M; Ghamlouch, Hussein; Rosikiewicz, Wojciech et al. (2018) TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis. Cancer Discov 8:1632-1653
Paigen, Kenneth; Petkov, Petko M (2018) PRDM9 and Its Role in Genetic Recombination. Trends Genet 34:291-300
Schloss, Jennifer; Ali, Riyasat; Racine, Jeremy J et al. (2018) HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression. J Immunol 200:3353-3363
Nakatsuji, Teruaki; Chen, Tiffany H; Butcher, Anna M et al. (2018) A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv 4:eaao4502
Racine, Jeremy J; Stewart, Isabel; Ratiu, Jeremy et al. (2018) Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. Diabetes 67:923-935
Ye, Fengdan; Jia, Dongya; Lu, Mingyang et al. (2018) Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma. Oncotarget 9:15015-15026

Showing the most recent 10 out of 1156 publications