Abstract

The Jackson Laboratory (TJL) was founded in 1929 by Dr. Clarence Cook Little as a mammalian genetics research center focusing on the problem of cancer. The long term goal of TJL Cancer Center program is to contribute to basic understanding of the genetic determinants of cancer. Expertise in the genetics and biology of the laboratory mouse is the predominant strength of TJL Cancer Center and is the centerpiece of the cancer research conducted here. The mouse represents a powerful mammalian model for human genetic organization and regulation, modes of inheritance, and disease. Researchers are identifying sets of associated genes participating in complex diseases and beginning to elucidate their modes of interaction. Epigenetic factors influencing gene action, mutagenesis, and cancer risk are being isolated and identified. Other investigators are discovering the molecular regulation of developmental processes, the dysregulation of which can lead to cellular transformation. A wide array of inbred, congenic, and mutant strains of mice are available for investigations into the control of immune functions and development of immunotherapies for cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA034196-16S1
Application #
6012549
Study Section
Cancer Centers and Research Programs Review Committee (CCRP)
Project Start
1996-08-25
Project End
2001-07-31
Budget Start
1999-01-01
Budget End
1999-07-31
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Mistri, Tapan Kumar; Arindrarto, Wibowo; Ng, Wei Ping et al. (2018) Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through Fgf4/Fgfr2 signaling in preimplantation mouse embryos. Biochem J 475:1075-1089
Leidy-Davis, Tiffany; Cheng, Kai; Goodwin, Leslie O et al. (2018) Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches. Sci Rep 8:15028
Raghupathy, Narayanan; Choi, Kwangbom; Vincent, Matthew J et al. (2018) Hierarchical analysis of RNA-seq reads improves the accuracy of allele-specific expression. Bioinformatics 34:2177-2184
Presa, Maximiliano; Racine, Jeremy J; Dwyer, Jennifer R et al. (2018) A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice. J Immunol 201:1907-1917
Pullagura, Sri Ramulu N; Buaas, Bill; Gray, Nichelle et al. (2018) Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During Murine Embryogenesis Does Not Involve miRNA Biogenesis. Genetics 208:1513-1522
Cho, Sung-Yup; Sung, Chang Ohk; Chae, Jeesoo et al. (2018) Alterations in the Rho pathway contribute to Epstein-Barr virus-induced lymphomagenesis in immunosuppressed environments. Blood 131:1931-1941
Chang, Bo; FitzMaurice, Bernard; Wang, Jieping et al. (2018) Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele. Invest Ophthalmol Vis Sci 59:5127-5139
Kong, Yang; Naggert, Jürgen K; Nishina, Patsy M (2018) The Impact of Adherens and Tight Junctions on Physiological Function and Pathological Changes in the Retina. Adv Exp Med Biol 1074:545-551
Shi, Jiayuan; Hua, Li; Harmer, Danielle et al. (2018) Cre Driver Mice Targeting Macrophages. Methods Mol Biol 1784:263-275
Sharma, Manju; Braun, Robert E (2018) Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis. Development 145:

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