The Veterinary Medicine Resource, part of the Laboratory Animal Sciences program, supports The Jackson Laboratory (TJL) Cancer Center investigators by ensuring the health and productivity of their mice. This is accomplished through: 1) a rigorous health and environmental monitoring program; 2) the provision of veterinary care for animals that are injured or suffering from non-infectious disease; and 3) clinical investigations into possible infectious disease problems. In addition, the Veterinary Medicine Resources provides surgically altered mice as requested by Cancer Center investigators. Over the next grant cycle, all Cancer Center mice will be brought to a uniform high health status through a program of rederivation to eliminate several opportunistic microorganisms that are harbored by many TJL research mice. Although not overt pathogens, these microorganisms represent a health threat to immune-deficient mice, and can affect the outcome of research using immunocompetent mice. Rederivation will be performed in conjunction with the Cryopreservation and Rederivation Resource using several approaches, including recovery from cryopreservation, embryo transfer, ovarian transplantation, and hysterectomy derivation. Peggy J. Danneman, V.M.D., M.S., Chief of the Veterinary Medicine Resource and Attending Veterinarian directs all Veterinary Medicine programs and will have primary oversight for the rederivation program. Abigail Smith, Ph.D., Director of Laboratory Animal Sciences, is responsible for overall coordination of the animal health programs. Funds are also requested as partial support for 3 individuals who will be responsible for the day-to-day implementation of the rederivation effort.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA034196-19
Application #
6502391
Study Section
Project Start
1996-08-25
Project End
2006-07-31
Budget Start
Budget End
Support Year
19
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Wu, Te-Chia; Xu, Kangling; Martinek, Jan et al. (2018) IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer. Cancer Res 78:5243-5258
Muscat, Andrea M; Wong, Nicholas C; Drummond, Katharine J et al. (2018) The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection. Oncotarget 9:7844-7858
Kohar, Vivek; Lu, Mingyang (2018) Role of noise and parametric variation in the dynamics of gene regulatory circuits. NPJ Syst Biol Appl 4:40
NĂ©bor, Danitza; Graber, Joel H; Ciciotte, Steven L et al. (2018) Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis. Sci Rep 8:12793
Linn, Sarah C; Mustonen, Allison M; Silva, Kathleen A et al. (2018) Nail abnormalities identified in an ageing study of 30 inbred mouse strains. Exp Dermatol :
Hosur, Vishnu; Farley, Michelle L; Burzenski, Lisa M et al. (2018) ADAM17 is essential for ectodomain shedding of the EGF-receptor ligand amphiregulin. FEBS Open Bio 8:702-710
Becker, Timothy; Lee, Wan-Ping; Leone, Joseph et al. (2018) FusorSV: an algorithm for optimally combining data from multiple structural variation detection methods. Genome Biol 19:38
Wang, Qianghu; Hu, Baoli; Hu, Xin et al. (2018) Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell 33:152
Richter, Wolfgang F; Christianson, Gregory J; Frances, Nicolas et al. (2018) Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice. MAbs 10:803-813
Tamura, Ryo; Yoshihara, Kosuke; Saito, Tetsuya et al. (2018) Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions. Oncogenesis 7:4

Showing the most recent 10 out of 1156 publications