Abstract

The Bioinformatics Shared Resource, located in the Eppley Institute (EI 5019) provides Cancer Center researchers with computational and informational tools for intensive searching and processing structural and functional information on biologically important molecules. Bioinformatics tools have become vital for the further progress in disciplines such as structural biology and structural and functional genetics. These tools allow researchers to organize structural and functional data, to extract the relevant information, and to present it to a broad circle of basic and clinical researchers using dynamic, interactive Intranet and Internet tools. The computational assets of the Bioinformatics Shared Resource are available 24-hours-a-day, seven-days-a-week through the global connectivity of personal computers at UNMC with the state-of-the-art workstations and software housed in the facilities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA036727-24
Application #
7666987
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
24
Fiscal Year
2008
Total Cost
$104,353
Indirect Cost

  Institution

Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198

  Publications

Wiest, Edwin J; Smith, Heather Jensen; Hollingsworth, Michael A (2018) Met receptor inhibitor SU11274 localizes in the endoplasmic reticulum. Biochem Biophys Res Commun 501:858-862
Kevadiya, Bhavesh D; Woldstad, Christopher; Ottemann, Brendan M et al. (2018) Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution. Theranostics 8:256-276
Uppada, Srijayaprakash Babu; Gowrikumar, Saiprasad; Ahmad, Rizwan et al. (2018) MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/?-catenin signaling. Mol Cancer 17:111
Leiphrakpam, Premila D; Brattain, Michael G; Black, Jennifer D et al. (2018) TGF? and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells. J Biol Chem 293:8242-8254
Won, Harim I; Schulze, Thomas T; Clement, Emalie J et al. (2018) De novo Assembly of the Burying Beetle Nicrophorus orbicollis (Coleoptera: Silphidae) Transcriptome Across Developmental Stages with Identification of Key Immune Transcripts. J Genomics 6:41-52
Zhou, Jiuli; Zeng, Yongji; Cui, Lian et al. (2018) Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation. Proc Natl Acad Sci U S A 115:E6760-E6769
Das, Binita; Neilsen, Beth K; Fisher, Kurt W et al. (2018) A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells. Sci Rep 8:3770
Qazi, Asif Khurshid; Siddiqui, Jawed A; Jahan, Rahat et al. (2018) Emerging therapeutic potential of graviola and its constituents in cancers. Carcinogenesis 39:522-533
Hsu, Alice H; Lum, Michelle A; Shim, Kang-Sup et al. (2018) Crosstalk between PKC? and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep 24:655-669
Svechkarev, Denis; Sadykov, Marat R; Bayles, Kenneth W et al. (2018) Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis. ACS Sens 3:700-708

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