Abstract

The purpose of the Monoclonal Antibody Shared Resource is to develop, produce and characterize monoclonal antibodies for Cancer Center members. To accomplish this, we have developed a large repertoire of protocols, from animal work to purification of genetically engineered antibodies. In addition, we devote our research and development efforts to the improvement of our services. The facility also maintains a BiaCore Instrument for antibody characterization. The Shared Resource stores over 8,000 vials of frozen cell lines for numerous Cancer Center members. The facility is directed by Dr. Don Johnson (Associate Professor, Department of Pathology & Microbiology, UNMC).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA036727-24
Application #
7666989
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
24
Fiscal Year
2008
Total Cost
$22,395
Indirect Cost

  Institution

Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198

  Publications

Zhou, Jiuli; Zeng, Yongji; Cui, Lian et al. (2018) Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation. Proc Natl Acad Sci U S A 115:E6760-E6769
Won, Harim I; Schulze, Thomas T; Clement, Emalie J et al. (2018) De novo Assembly of the Burying Beetle Nicrophorus orbicollis (Coleoptera: Silphidae) Transcriptome Across Developmental Stages with Identification of Key Immune Transcripts. J Genomics 6:41-52
Qazi, Asif Khurshid; Siddiqui, Jawed A; Jahan, Rahat et al. (2018) Emerging therapeutic potential of graviola and its constituents in cancers. Carcinogenesis 39:522-533
Das, Binita; Neilsen, Beth K; Fisher, Kurt W et al. (2018) A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells. Sci Rep 8:3770
Svechkarev, Denis; Sadykov, Marat R; Bayles, Kenneth W et al. (2018) Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis. ACS Sens 3:700-708
Hsu, Alice H; Lum, Michelle A; Shim, Kang-Sup et al. (2018) Crosstalk between PKC? and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep 24:655-669
Qi, Bowen; Crawford, Ayrianne J; Wojtynek, Nicholas E et al. (2018) Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer. Nanomedicine 14:769-780
Contreras, Jacob I; Robb, Caroline M; King, Hannah M et al. (2018) Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy. ACS Chem Biol 13:1148-1152
Svechkarev, Denis; Mohs, Aaron M (2018) Organic fluorescent dye-based nanomaterials: Advances in the rational design for imaging and sensing applications. Curr Med Chem :
Berger, Ann M; Kupzyk, Kevin A; Djalilova, Dilorom M et al. (2018) Breast Cancer Collaborative Registry informs understanding of factors predicting sleep quality. Support Care Cancer :

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