Overall The Fred & Pamela Buffett Cancer Center (Buffett Cancer Center or FPBCC) at the University of Nebraska Medical Center is committed to developing new strategies for the treatment and prevention of cancer through innovative interdisciplinary research, premier educational programs, the highest quality patient care, and outreach to underserved populations. The Buffett Cancer Center is dedicated to reducing the burden of cancer through interdisciplinary translational cancer research leading to new therapies for cancer treatment as well as enhancing the well-being of cancer survivors. As the only NCI-designated Cancer Center in Nebraska, we are very sensitive to the needs of the underserved populations in our catchment area (across the state of Nebraska and western Iowa), including women, minorities and children as well as the medically underserved rural residents in our region. The 84 members of the Buffett Cancer Center are actively involved in the interdisciplinary FPBCC Research Programs including the Molecular and Biochemical Etiology Program (MBEP), the Cancer Genes and Molecular Regulation Program (CGMR), and the Gastrointestinal Cancer Program (GICP). The FBPCC is a matrix with Members in each of the Colleges and Institutes at UNMC, as well as Members at the University of Nebraska - Lincoln and the University of Nebraska - Omaha. The FPBCC Director also leads the Eppley Cancer Institute, with 30 tenure/tenure-leading faculty appointments. The FPBCC Director reports directly to the Chancellor of UNMC and serves on the UNMC Chancellor's Council and the Nebraska Medicine's Senior Leadership Team, the two most senior and responsible cabinets of the the academic and the clinical enterprise. A new $323 M Buffett Cancer Center (625,000 gsf) will open in 2017 integrating cancer research and care in one facility and provide ample room FPBCC growth. Since the last review, the FPBCC enhanced interdisciplinary research collaborations by providing support for recruitment of 30 new Members (including the co-leaders of the GICP and the Director of the Bioinformatics Shared Resource), for enhancements to shared research facilities, and for pilot funding for collaborative multidisciplinary research projects. The FPBCC has a robust track record of transdisciplinary cancer research and strong evidence of collaborations bridging all of the Research Programs. Buffett Cancer Center research has resulted in 1409 publications of which 23% are inter-programmatic collaborations, 23% are intra-programmatic collaborations and 9% are both. FPBCC externally funded cancer research portfolio which currently exceeds $34.3 M annually in peer-reviewed support (> 46% NCI) demonstrates university-wide transdisciplinary cancer research collaborations by Buffett Cancer Center Members focused on resolving cancer-related problems.

Public Health Relevance

Overall The mission of the Fred and Pamela Buffett Cancer Center (FPBCC), formerly known as the UNMC Eppley Cancer Center, is to understand, prevent and cure cancer in Nebraska through premier educational programs, innovative research, the highest quality patient care, and outreach to underserved populations.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA036727-34
Application #
9981635
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Belin, Precilla L
Project Start
1997-09-05
Project End
2021-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
34
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Nebraska Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198
Kevadiya, Bhavesh D; Woldstad, Christopher; Ottemann, Brendan M et al. (2018) Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution. Theranostics 8:256-276
Wiest, Edwin J; Smith, Heather Jensen; Hollingsworth, Michael A (2018) Met receptor inhibitor SU11274 localizes in the endoplasmic reticulum. Biochem Biophys Res Commun 501:858-862
Leiphrakpam, Premila D; Brattain, Michael G; Black, Jennifer D et al. (2018) TGF? and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells. J Biol Chem 293:8242-8254
Uppada, Srijayaprakash Babu; Gowrikumar, Saiprasad; Ahmad, Rizwan et al. (2018) MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/?-catenin signaling. Mol Cancer 17:111
Won, Harim I; Schulze, Thomas T; Clement, Emalie J et al. (2018) De novo Assembly of the Burying Beetle Nicrophorus orbicollis (Coleoptera: Silphidae) Transcriptome Across Developmental Stages with Identification of Key Immune Transcripts. J Genomics 6:41-52
Zhou, Jiuli; Zeng, Yongji; Cui, Lian et al. (2018) Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation. Proc Natl Acad Sci U S A 115:E6760-E6769
Das, Binita; Neilsen, Beth K; Fisher, Kurt W et al. (2018) A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells. Sci Rep 8:3770
Qazi, Asif Khurshid; Siddiqui, Jawed A; Jahan, Rahat et al. (2018) Emerging therapeutic potential of graviola and its constituents in cancers. Carcinogenesis 39:522-533
Hsu, Alice H; Lum, Michelle A; Shim, Kang-Sup et al. (2018) Crosstalk between PKC? and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep 24:655-669
Svechkarev, Denis; Sadykov, Marat R; Bayles, Kenneth W et al. (2018) Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis. ACS Sens 3:700-708

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