Abstract

UNMC Advanced Microscopy Core Facility (UAMCF) The UNMC Advanced Microscopy Core Facility (UAMCF) at the University of Nebraska Medical Center is dedicated to providing top-notch microscopy and imaging services for competitive fees. Over the past funding period, the UAMCF has undergone a leadership change with a new Director who is committed to developing and maintaining a world-class microscopy facility with cutting-edge technologies to drive innovative research at UNMC. UAMCF has recently obtained a dual-platform super-resolution microscope with capabilities for super- resolution Structured Illumination Microscopy (sr-SIM) and single-molecule Photoactivatible Localization Microscopy/direct Stochastic Optical Reconstruction Microscopy. Sr-SIM capabilities include up to 100 nm resolution in the x/y axis, and ~300 nm axial resolution. PALM/dSTORM capabilities include single-molecule imaging and precision of ~5 nm coupled with ~10 nm Nyquiste Resolution. The facility provides outstanding service, including consultations by active researchers with expertise who have published studies using advanced microscopy techniques. Coupled with standard confocal microscopy provided by the facility, the UAMCF provides outstanding support for Cancer Center and other researchers on campus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA036727-34
Application #
9981644
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-09-05
Project End
2021-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
34
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198

  Publications

Won, Harim I; Schulze, Thomas T; Clement, Emalie J et al. (2018) De novo Assembly of the Burying Beetle Nicrophorus orbicollis (Coleoptera: Silphidae) Transcriptome Across Developmental Stages with Identification of Key Immune Transcripts. J Genomics 6:41-52
Zhou, Jiuli; Zeng, Yongji; Cui, Lian et al. (2018) Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation. Proc Natl Acad Sci U S A 115:E6760-E6769
Das, Binita; Neilsen, Beth K; Fisher, Kurt W et al. (2018) A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells. Sci Rep 8:3770
Qazi, Asif Khurshid; Siddiqui, Jawed A; Jahan, Rahat et al. (2018) Emerging therapeutic potential of graviola and its constituents in cancers. Carcinogenesis 39:522-533
Hsu, Alice H; Lum, Michelle A; Shim, Kang-Sup et al. (2018) Crosstalk between PKC? and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep 24:655-669
Svechkarev, Denis; Sadykov, Marat R; Bayles, Kenneth W et al. (2018) Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis. ACS Sens 3:700-708
Contreras, Jacob I; Robb, Caroline M; King, Hannah M et al. (2018) Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy. ACS Chem Biol 13:1148-1152
Qi, Bowen; Crawford, Ayrianne J; Wojtynek, Nicholas E et al. (2018) Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer. Nanomedicine 14:769-780
Berger, Ann M; Kupzyk, Kevin A; Djalilova, Dilorom M et al. (2018) Breast Cancer Collaborative Registry informs understanding of factors predicting sleep quality. Support Care Cancer :
Svechkarev, Denis; Mohs, Aaron M (2018) Organic fluorescent dye-based nanomaterials: Advances in the rational design for imaging and sensing applications. Curr Med Chem :

Showing the most recent 10 out of 1372 publications