Abstract

The Huntsman Cancer Institute (HCI) is committed to the development of new approaches to reducing the morbidity and mortality due to cancer. The main focus is on the major adult epithelial tumors, breast, prostate, colon, and aerodigestive. A major research theme of the HCI is the development of new approaches to very early diagnosis and treatment based on the emerging knowledge of the earliest molecular changes in tumorigenesis. This builds on our traditional strength in molecular genetics, which has opened a window into the earliest changes in carcinogenesis. Traditional, discipline-oriented Programs will continue to underlie our primary organizational structure. However, our primary approach will be implemented through a series of new, interdisciplinary, translational Programs focused on the molecular genetics, biology, diagnosis, and therapy of the individual tumor types.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA042014-11S1
Application #
2800613
Study Section
Cancer Centers and Research Programs Review Committee (CCRP)
Program Officer
Vembu, Devi
Project Start
1986-07-01
Project End
1999-04-30
Budget Start
1997-05-09
Budget End
1999-04-30
Support Year
11
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Vahrenkamp, Jeffery M; Yang, Chieh-Hsiang; Rodriguez, Adriana C et al. (2018) Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor ? In Endometrial Cancer. Cell Rep 22:2995-3005
Gupta, Sumati; Albertson, Daniel; Gaston, David et al. (2018) Comprehensive Genomic Sequencing of Urothelial Tumors Identifies Rare SMARCB1 (INI-1)-Deficient Carcinomas of the Urinary System. Clin Genitourin Cancer 16:e373-e382
Yazdimamaghani, Mostafa; Moos, Philip J; Ghandehari, Hamidreza (2018) Global gene expression analysis of macrophage response induced by nonporous and porous silica nanoparticles. Nanomedicine 14:533-545
Al-Agha, Abdulmoein Eid; Ahmed, Ihab Abdulhamed; Nuebel, Esther et al. (2018) Primary Ovarian Insufficiency and Azoospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation. J Clin Endocrinol Metab 103:555-563
Petersen, Jenna; Koptiuch, Cathryn; Wu, Yelena P et al. (2018) Patterns of family communication and preferred resources for sharing information among families with a Lynch syndrome diagnosis. Patient Educ Couns 101:2011-2017
Flack, Caralyn E; Parkinson, John S (2018) A zipped-helix cap potentiates HAMP domain control of chemoreceptor signaling. Proc Natl Acad Sci U S A 115:E3519-E3528
Blackburn, Brenna E; Ganz, Patricia A; Rowe, Kerry et al. (2018) Reproductive and gynecological complication risks among thyroid cancer survivors. J Cancer Surviv 12:702-711
Wu, Yelena P; Aspinwall, Lisa G; Nagelhout, Elizabeth et al. (2018) Development of an Educational Program Integrating Concepts of Genetic Risk and Preventive Strategies for Children with a Family History of Melanoma. J Cancer Educ 33:774-781
Pishas, Kathleen I; Drenberg, Christina D; Taslim, Cenny et al. (2018) Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response. Mol Cancer Ther 17:1902-1916
Spiker, William Ryan; Brodke, Darrel S; Goz, Vadim et al. (2018) Evidence of an Inherited Predisposition for Spinal Cord Tumors. Global Spine J 8:340-344

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