Abstract

Colon cancer, which affects men and women equally, is the second most common cause of cancer death in the U.S. The overall goal of the colon cancer program is the prevention of this malignancy through understanding its biology and pathogenesis. The adenomatous polyp, the precursor of colon cancer, is a central theme of our investigations both as a clinical and biologic marker of colon cancer risk and development. The program includes a broad spectrum of integrated projects ranging from the most basic genetic and biologic studies to clinical screening and prevention investigations. Under a translational structure, investigators will: clinically and genetically define familial risk of colon cancer, determine the cellular mechanisms of APC protein function; determine the cellular consequences and mechanisms and effects of cyclo- oxygenase over-expression in normal colonic and neoplastic tissues; examine genetic-environmental interactions in the pathogenesis of colon cancer; and test chemoprevention agents against GI neoplasms. A supporting infrastructure has been developed to accomplish this work which includes: a familial colon cancer clinical and registry, a genetic counseling service, a general CRC with endoscopic capabilities, a population data base for access of familial cases, and a regional gastroenterology network for access and care of patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042014-13
Application #
6334946
Study Section
Project Start
2000-07-25
Project End
2001-04-30
Budget Start
Budget End
Support Year
13
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Trott, Daniel W; Henson, Grant D; Ho, Mi H T et al. (2018) Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp Gerontol 109:99-107
Wu, Yelena P; Parsons, Bridget G; Mooney, Ryan et al. (2018) Barriers and Facilitators to Melanoma Prevention and Control Behaviors Among At-Risk Children. J Community Health 43:993-1001
Zabriskie, Matthew S; Antelope, Orlando; Verma, Anupam R et al. (2018) A novel AGGF1-PDGFRb fusion in pediatric T-cell acute lymphoblastic leukemia. Haematologica 103:e87-e91
Wolff, Roger K; Hoffman, Michael D; Wolff, Erica C et al. (2018) Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers. Genes Chromosomes Cancer 57:366-376
Hellwig, Sabine; Nix, David A; Gligorich, Keith M et al. (2018) Automated size selection for short cell-free DNA fragments enriches for circulating tumor DNA and improves error correction during next generation sequencing. PLoS One 13:e0197333
Fleming, Aaron M; Zhu, Judy; Ding, Yun et al. (2018) Human DNA Repair Genes Possess Potential G-Quadruplex Sequences in Their Promoters and 5'-Untranslated Regions. Biochemistry 57:991-1002
Martin, Christopher; Leiser, Claire L; O'Neil, Brock et al. (2018) Familial Cancer Clustering in Urothelial Cancer: A Population-Based Case-Control Study. J Natl Cancer Inst 110:527-533
Mollaoglu, Gurkan; Jones, Alex; Wait, Sarah J et al. (2018) The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Immunity 49:764-779.e9
Sorenson, Reed S; Deshotel, Malia J; Johnson, Katrina et al. (2018) Arabidopsis mRNA decay landscape arises from specialized RNA decay substrates, decapping-mediated feedback, and redundancy. Proc Natl Acad Sci U S A 115:E1485-E1494
Polanco, Edward R; Western, Nicholas; Zangle, Thomas A (2018) Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics. J Vis Exp :

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