RESEARCH INFORMATICS SHARED RESOURCE ABSTRACT The Research Informatics (RI) Shared Resource, established in 1995, provides Cancer Center members state- of-the-art software engineering, database design, and application and web development, as well as cutting- edge expertise in natural language processing, system design, data mining, and electronic data capture systems. Huntsman Cancer Institute (HCI) covers a majority of the costs of this stable, integrated team of computer professionals, enabling their allocation to the ongoing and new initiatives of highest importance to the cancer mission; priorities are determined by the HCI Director's Cabinet. Samir Courdy, BS, MBA, an accomplished computer scientist with expertise in software engineering and development of large-scale software systems, has directed the RI Shared Resource since 2006 and has managed all software development since 2000. Ms. Cindy Spigle, associate director of the RI Resource since 2011, is responsible for daily operations and assists Mr. Courdy in management. To achieve its goals, the RI Shared Resource provides computing infrastructure, hardware equipment, and services, including the latest advances in front-end graphical user interface (GUI) technologies and secure backend database engines and persistence layers. The RI Shared Resource has developed applications and databases for several other HCI-managed Shared Resources, including High-Throughput Genomics and Bioinformatic Analysis, Genetic Counseling, Biorepository and Molecular Pathology, and the Utah Population Database. The RI Shared Resource supports all four of the Cancer Center's Research Programs with the many software suites the team designs, builds, and supports. These include comprehensive suites of software applications for Cancer Clinical Research (CCR); Biospecimen Management and Annotation (itBioPath); a microarray and next-generation sequencing Laboratory Information Management System (LIMS) and experiment analysis and annotation suite (GNomEx); and a drug/chemical screening annotation and management suite (CSAM). CCR, itBioPath, and GNomEx are integrated systems providing genotype and phenotype associations for research. As software development is beyond the budget of most individual researchers, the RI Shared Resource adds important value to the Cancer Center by enabling a wide variety of researchers to utilize customized software tools without substantial financial investments. The Resource also provides cost savings to researchers by obtaining grant and institutional support to help offset software development costs. In 2013, use of the RI Shared Resource by Cancer Center members with peer-reviewed funding exceeded 57%, while the CCSG budget request is only 6% ($123,370) of the total proposed budget.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042014-27
Application #
9149884
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Ptak, Krzysztof
Project Start
Project End
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
27
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Vahrenkamp, Jeffery M; Yang, Chieh-Hsiang; Rodriguez, Adriana C et al. (2018) Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor ? In Endometrial Cancer. Cell Rep 22:2995-3005
Gupta, Sumati; Albertson, Daniel; Gaston, David et al. (2018) Comprehensive Genomic Sequencing of Urothelial Tumors Identifies Rare SMARCB1 (INI-1)-Deficient Carcinomas of the Urinary System. Clin Genitourin Cancer 16:e373-e382
Yazdimamaghani, Mostafa; Moos, Philip J; Ghandehari, Hamidreza (2018) Global gene expression analysis of macrophage response induced by nonporous and porous silica nanoparticles. Nanomedicine 14:533-545
Petersen, Jenna; Koptiuch, Cathryn; Wu, Yelena P et al. (2018) Patterns of family communication and preferred resources for sharing information among families with a Lynch syndrome diagnosis. Patient Educ Couns 101:2011-2017
Flack, Caralyn E; Parkinson, John S (2018) A zipped-helix cap potentiates HAMP domain control of chemoreceptor signaling. Proc Natl Acad Sci U S A 115:E3519-E3528
Al-Agha, Abdulmoein Eid; Ahmed, Ihab Abdulhamed; Nuebel, Esther et al. (2018) Primary Ovarian Insufficiency and Azoospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation. J Clin Endocrinol Metab 103:555-563
Blackburn, Brenna E; Ganz, Patricia A; Rowe, Kerry et al. (2018) Reproductive and gynecological complication risks among thyroid cancer survivors. J Cancer Surviv 12:702-711
Wu, Yelena P; Aspinwall, Lisa G; Nagelhout, Elizabeth et al. (2018) Development of an Educational Program Integrating Concepts of Genetic Risk and Preventive Strategies for Children with a Family History of Melanoma. J Cancer Educ 33:774-781
Pishas, Kathleen I; Drenberg, Christina D; Taslim, Cenny et al. (2018) Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response. Mol Cancer Ther 17:1902-1916
Spiker, William Ryan; Brodke, Darrel S; Goz, Vadim et al. (2018) Evidence of an Inherited Predisposition for Spinal Cord Tumors. Global Spine J 8:340-344

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