The UCLA Clinical Nutrition Research Unit (CNRU) supports the development of new interdisciplinary research in nutrition and cancer prevention which would not otherwise occur through provision of specialized core research services, pilot/feasibility study funds and a New Investigator Award. The Administrative and Nutrition Education Core has creatively expanded the influence of the CNRU at UCLA. We have established the UCLA Center for Human Nutrition as the focus of nutrition research, education and patient care at UCLA. Our NIH T32 Nutrition and Obesity Training Program has developed new junior faculty and we have recruited many new faculty to the CNRU. An NIH P50 Center for Botanical Dietary Supplements Research was funded in 1999 and led to collaboration with plant molecular biologists and funding of the UCLA Research Growth Center. The Gene-Nutrient Core has established new facilities with private funds for high throughput genotyping, and microarray analysis of gene expression and this has led to new funding. The Molecular Oncology Core provides expertise in studies of the multistep pathway of carcinogenesis. The Nutritional Biomarker Core has supported research with high quality lipid, hormone, and carotenoid measurement and established methods for quantitating dietary flavonoids and assessing oxidant stress supporting new funded research. The Stable Isotope Core has established methods for metabolic phenotyping of cancer cells, and supported phytochemical measurement by LCMS. The Dietary Intervention, Assessment and Body Composition Core has supported dietary intervention research, community-based diet assessment research, and body composition research. The Statistical Coordinating Unit Core has established new methods for analysis of national and local dietary intervention trials, analysis of data from gene-nutrient interaction studies and provided training in translational research. The UCLA CNRU is serving as a regional and national resource at the cutting edge of nutrition and cancer prevention research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042710-19
Application #
6748426
Study Section
Special Emphasis Panel (ZCA1-GRB-F (J1))
Program Officer
Milner, John A
Project Start
1985-09-30
Project End
2007-04-30
Budget Start
2004-08-03
Budget End
2005-04-30
Support Year
19
Fiscal Year
2004
Total Cost
$808,636
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Mao, Gloria E; Harris, Diane M; Moro, Aune et al. (2012) A joint effect of new Western diet and retinoid X receptor ? prostate-specific knockout with development of high-grade prostatic intraepithelial neoplasia in mice--a preliminary study. Prostate 72:1052-9
Hong, Mee Young; Henning, Susanne; Moro, Aune et al. (2011) Chinese red yeast rice inhibition of prostate tumor growth in SCID mice. Cancer Prev Res (Phila) 4:608-15
Heber, David (2010) An integrative view of obesity. Am J Clin Nutr 91:280S-283S
Lu, Qing-Yi; Yang, Yanan; Jin, Yu Sheng et al. (2009) Effects of green tea extract on lung cancer A549 cells: proteomic identification of proteins associated with cell migration. Proteomics 9:757-67
Nguyen, Anthony V; Martinez, Micaela; Stamos, Michael J et al. (2009) Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res 1:25-37
Boros, Laszlo G; Deng, Qinggao; Pandol, Stephen J et al. (2009) Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer. Pancreas 38:e47-52
Lu, Qing-Yi; Zhang, Yanjun; Wang, Yue et al. (2009) California Hass avocado: profiling of carotenoids, tocopherol, fatty acid, and fat content during maturation and from different growing areas. J Agric Food Chem 57:10408-13
Hong, Mee Young; Seeram, Navindra P; Heber, David (2008) Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. J Nutr Biochem 19:848-55
Hong, Mee Young; Seeram, Navindra P; Zhang, Yanjun et al. (2008) Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells. J Nutr Biochem 19:448-58
Li, Z; Aronson, W J; Arteaga, J R et al. (2008) Feasibility of a low-fat/high-fiber diet intervention with soy supplementation in prostate cancer patients after prostatectomy. Eur J Clin Nutr 62:526-36