The Case Western Reserve University/Ireland Cancer Center is a multi- disciplinary, clinical, and laboratory research center, combining the resources and expertise at Case Western Reserve University and University Hospitals of Cleveland, with the participation of two major affiliate hospitals-MetroHealth Medical Center and the Cleveland Department of Veterans Affairs Medical Center. The Cancer Center program spans 29 departments in the Schools of Medicine, Nursing, Engineering, and the College of Arts and Sciences at Case Western Reserve University. The objectives of the Case Western Reserve University/Ireland Cancer Center are: 1) to improve the prevention, diagnosis, and therapy of cancer through research; 2) to stimulate and support innovative, coordinated, interdisciplinary research on cancer diagnosis, treatment, and control; 3) to develop clinical applications of research discoveries and to make these applications available to Northeast Ohio residents as quickly as possible; and 4) to develop cancer prevention and control activities that most effectively utilize the clinical and laboratory expertise at Case Western Reserve University and contribute to the reduction of cancer morbidity and mortality in Northeast Ohio and the surrounding region. The goals of the center are accomplished by activities in six active programs (Molecular Biology of Oncogenesis, Molecular Virology, Cancer Genetics, Radiation Biology, Hematopoietic and Immune Cell Biology, and Developmental Therapeutics); one developing program (Cancer Prevention and Control); and ten shared resources (Molecular Biology, Flow Cytometry, Radiation Resources, Media Preparation, Histology, Athymic Animal, Hematopoietic Stem Cell, Clinical Pharmacology, Biostatistics/Epidemiology, and Clinical Trials.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA043703-12
Application #
6172548
Study Section
Cancer Centers and Research Programs Review Committee (CCRP)
Program Officer
Silkensen, Shannon M
Project Start
1991-09-30
Project End
2001-07-31
Budget Start
2000-08-25
Budget End
2001-07-31
Support Year
12
Fiscal Year
2000
Total Cost
$1,858,039
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Hubler, Zita; Allimuthu, Dharmaraja; Bederman, Ilya et al. (2018) Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 560:372-376
Asthana, Abhishek; Ramakrishnan, Parameswaran; Vicioso, Yorleny et al. (2018) Hexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell Death. Mol Cancer Ther 17:2226-2237
Belur Nagaraj, Anil; Kovalenko, Olga; Avelar, Rita et al. (2018) Mitotic Exit Dysfunction through the Deregulation of APC/C Characterizes Cisplatin-Resistant State in Epithelial Ovarian Cancer. Clin Cancer Res 24:4588-4601
Yang, Xiaosong; Pan, You; Qiu, Zhaojun et al. (2018) RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells. Clin Cancer Res 24:1629-1643
Liu, Xia; Taftaf, Rokana; Kawaguchi, Madoka et al. (2018) Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models. Cancer Discov :
Belur Nagaraj, Anil; Joseph, Peronne; Kovalenko, Olga et al. (2018) Evaluating class III antiarrhythmic agents as novel MYC targeting drugs in ovarian cancer. Gynecol Oncol 151:525-532
Li, Jiayang; Gresham, Kenneth S; Mamidi, Ranganath et al. (2018) Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy. Int J Cardiol 273:168-176
Enane, Francis O; Saunthararajah, Yogen; Korc, Murray (2018) Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells. Cell Death Dis 9:912
Lennon, Donald; Solchaga, Luis A; Somoza, Rodrigo A et al. (2018) Human and Rat Bone Marrow-Derived Mesenchymal Stem Cells Differ in Their Response to Fibroblast Growth Factor and Platelet-Derived Growth Factor. Tissue Eng Part A 24:1831-1843
Evans, Daniel R; Venkitachalam, Srividya; Revoredo, Leslie et al. (2018) Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer. Hum Mutat 39:1092-1101

Showing the most recent 10 out of 1227 publications