The Comprehensive Cancer Center of Case Western Reserve University (CWRU) and University Hospitals of Cleveland (UHC) is an NCI-designated Comprehensive Cancer Center that combines the resources and expertise of its two parent institutions. The Center is organized as a matrix center with seven interdisciplinary scientific programs and ten multidisciplinary disease-oriented clinical teams. Research programs of the Center extend to CWRU affiliated hospitals including the Louis Stokes Veterans Affairs Hospital, the MetroHealth Medical Center (the region?s county hospital), and the Henry Ford Health System in Detroit. Fourteen shared resources operated by the Center enable cancer research. A patient education and information office provides the 4.5 million people of the Northern Ohio region with information on cancer diagnosis, treatment and prevention, as well as information on access to clinical research trials. The Center has experienced dynamic growth during the past five years including the development of a new program in cancer prevention, control and population research, recruitment of twenty-four new members from outside the institution, and the development of four new shared resources. Membership in the Center has grown to 200 members representing 23 departments and 6 schools across the University. Strong institutional support including plans for new Cancer Center research space provide outstanding opportunities for this growth to continue. The objectives of the Center are: 1) to improve the prevention, diagnosis, and therapy of cancer through research; 2) to stimulate and support innovative, coordinated, interdisciplinary research on cancer diagnosis, treatment, and control; 3) to develop clinical applications of research discoveries and to make these applications available to Northeastern Ohio residents as quickly as possible; and 4) to develop cancer prevention and control activities that most effectively utilize the clinical and laboratory expertise at CWRU and UHC and contribute to the reduction of cancer morbidity and mortality in Northeast Ohio and the surrounding region and nation.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA043703-17S2
Application #
7289041
Study Section
Subcommittee G - Education (NCI)
Program Officer
Silkensen, Shannon M
Project Start
1991-09-30
Project End
2007-07-31
Budget Start
2005-08-01
Budget End
2007-07-31
Support Year
17
Fiscal Year
2006
Total Cost
$129,549
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Qiu, Zhaojun; Oleinick, Nancy L; Zhang, Junran (2018) ATR/CHK1 inhibitors and cancer therapy. Radiother Oncol 126:450-464
Elitt, Matthew S; Shick, H Elizabeth; Madhavan, Mayur et al. (2018) Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease. Stem Cell Reports 11:711-726
He, Tian; McColl, Karen; Sakre, Nneha et al. (2018) Post-transcriptional regulation of PIAS3 expression by miR-18a in malignant mesothelioma. Mol Oncol 12:2124-2135
Roche, Kathryn L; Nukui, Masatoshi; Krishna, Benjamin A et al. (2018) Selective 4-Thiouracil Labeling of RNA Transcripts within Latently Infected Cells after Infection with Human Cytomegalovirus Expressing Functional Uracil Phosphoribosyltransferase. J Virol 92:
Bedell, Hillary W; Hermann, John K; Ravikumar, Madhumitha et al. (2018) Targeting CD14 on blood derived cells improves intracortical microelectrode performance. Biomaterials 163:163-173
Nagaraj, A B; Wang, Q Q; Joseph, P et al. (2018) Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment. Oncogene 37:403-414
Somasegar, Sahana; Li, Li; Thompson, Cheryl L (2018) No association of reproductive risk factors with breast cancer tumor grade. Eur J Cancer Prev 27:140-143
Gu, Xiaorong; Ebrahem, Quteba; Mahfouz, Reda Z et al. (2018) Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates. J Clin Invest 128:4260-4279
Bosca, Federica; Bielecki, Peter A; Exner, Agata A et al. (2018) Porphyrin-Loaded Pluronic Nanobubbles: A New US-Activated Agent for Future Theranostic Applications. Bioconjug Chem 29:234-240
Benson, Bryan L; Li, Lucy; Myers, Jay T et al. (2018) Biomimetic post-capillary venule expansions for leukocyte adhesion studies. Sci Rep 8:9328

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