The catchment area of Case Comprehensive Cancer Center (Case CCC) is the 15-county region in Northeast Ohio surrounding the City of Cleveland with a census of 4 million individuals, in which about 80% of the cancer patients seen at consortium hospitals reside. Of note, within this 15-county region, 62% of all cancer patients are seen at a consortium hospital site. Over the past 5 years, Case CCC has impacted the catchment area and beyond with thoughtful community-engaged research and outreach programs. The Center has recognized poverty as an important root cause of cancer disparities, and assembled a team of investigators, local government, and the safety-net provider network to engage communities for interventions on poverty and cancer prevention, and early detection services. The overarching goals of the Community Outreach and Engagement component are to build capacity for 1) collaborative, community-focused cancer research of relevance to the catchment area, and 2) outreach programs to increase cancer awareness and knowledge, and effective patient navigation.
Specific aims of the Community Outreach and Engagement component are to: 1. Implement population-based approaches to understand cancer burden in the catchment area and to guide scientific inquiry on distinct cancer-related challenges. 2. Use knowledge of the distinct cancer issues in the catchment area to stimulate new scientific discoveries, and disseminate findings into the population at large, including underserved communities. 3. Promote cancer disparities reduction and health equity through an inclusive research environment. The Case CCC is also addressing the high rates of lung cancer by strategically focusing on primary and tertiary prevention, including the implementation of a tobacco Quit Line eReferral system at the MetroHealth System, and providing data and testimony that were instrumental in passing the Tobacco 21 law in the city of Cleveland in 2015. Case CCC has established a Community Advisory Board (CAB) to guide catchment area research, and recently established the Office of Cancer Disparities Research (OCDR) to support, coordinate, and foster interdisciplinary cancer disparities research, training, and outreach program evaluation. Collectively, this program seeks to demonstrate the Case CCC?s commitment to working together to enhance the discovery process, promote innovative and community-changing collaborations, educate and motivate the citizens of Northeast Ohio and beyond, and conduct research across the Center?s Research Programs of direct relevance to the catchment area.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA043703-28
Application #
9488779
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-05-10
Budget End
2019-03-31
Support Year
28
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Hubler, Zita; Allimuthu, Dharmaraja; Bederman, Ilya et al. (2018) Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 560:372-376
Asthana, Abhishek; Ramakrishnan, Parameswaran; Vicioso, Yorleny et al. (2018) Hexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell Death. Mol Cancer Ther 17:2226-2237
Belur Nagaraj, Anil; Kovalenko, Olga; Avelar, Rita et al. (2018) Mitotic Exit Dysfunction through the Deregulation of APC/C Characterizes Cisplatin-Resistant State in Epithelial Ovarian Cancer. Clin Cancer Res 24:4588-4601
Yang, Xiaosong; Pan, You; Qiu, Zhaojun et al. (2018) RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells. Clin Cancer Res 24:1629-1643
Liu, Xia; Taftaf, Rokana; Kawaguchi, Madoka et al. (2018) Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models. Cancer Discov :
Belur Nagaraj, Anil; Joseph, Peronne; Kovalenko, Olga et al. (2018) Evaluating class III antiarrhythmic agents as novel MYC targeting drugs in ovarian cancer. Gynecol Oncol 151:525-532
Li, Jiayang; Gresham, Kenneth S; Mamidi, Ranganath et al. (2018) Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy. Int J Cardiol 273:168-176
Enane, Francis O; Saunthararajah, Yogen; Korc, Murray (2018) Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells. Cell Death Dis 9:912
Lennon, Donald; Solchaga, Luis A; Somoza, Rodrigo A et al. (2018) Human and Rat Bone Marrow-Derived Mesenchymal Stem Cells Differ in Their Response to Fibroblast Growth Factor and Platelet-Derived Growth Factor. Tissue Eng Part A 24:1831-1843
Evans, Daniel R; Venkitachalam, Srividya; Revoredo, Leslie et al. (2018) Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer. Hum Mutat 39:1092-1101

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