The Biomolecular Analysis Facility (BAF) provides a centralized setting for a diverse but interactive suite of services, instrumentation, and expertise in the areas of genomics, transcriptomics, proteomics, metabolomics, lipidomics, and molecular interactions. BAF research services have been provided to the Cancer Center for nearly 20 years, with recent additions addressing new areas of investigator need identified by the Cancer Center Executive Committee. The highly skilled staff has the necessary expertise to provide Cancer Center members with not only rapid, high quality data but also with pre- and post-experiment consultation necessary for successful experiments. This complete approach to service gives investigators confidence in their work leading to publications and additional grants. The labs, instruments, and personnel of the BAF are all located on the first floor of Jordan Hall allowing Cancer Center members to easily utilize and integrate multiple `omics' techniques in their research. In addition, the BAF has significant ties to other Cancer Center shared resources such as Flow Cytometry, Biorepository and Tissue Research Facility, Animal Models of Disease, and Advanced Microscopy Facility. In some cases, these facilities provide the samples/material utilized in the BAF while in others they use BAF-generated results to initiate further research experiments. One key area of focus within the BAF is providing access to advanced instrumentation and experiments that meet Cancer Center needs. Within the past year, the facility has added two mass spectrometers in the area of lipidomics and metabolomics and an instrument capable of measuring molecular interactions. As the majority of BAF users are Cancer Center members, the interaction with these investigators is the driving force for acquisition of new instrumentation and development of new techniques. The Cancer Center Executive Committee and Office of Research Core Administration (ORCA ? within School of Medicine Dean's Office) work closely together to foster this environment. To that end the School of Medicine provides direct budget support to the BAF every year (~30% total budget). When the Cancer Center co-pay is combined with the School of Medicine's support, Cancer Center Members receive highly effective services at a price that makes more experiments possible.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA044579-30
Application #
10091428
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-09-16
Project End
2022-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
30
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Virginia
Department
Type
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Wang, T Tiffany; Yang, Jun; Zhang, Yong et al. (2018) IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective ?-chain cytokines, decreases leukemic T-cell viability. Leukemia :
Yao, Nengliang; Zhu, Xi; Dow, Alan et al. (2018) An exploratory study of networks constructed using access data from an electronic health record. J Interprof Care :1-8
Kiran, Shashi; Dar, Ashraf; Singh, Samarendra K et al. (2018) The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers. Mol Cell 72:823-835.e5
Conaway, Mark R; Petroni, Gina R (2018) The Impact of Early-Phase Trial Design in the Drug Development Process. Clin Cancer Res :
Szlachta, Karol; Kuscu, Cem; Tufan, Turan et al. (2018) CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response. Nat Commun 9:4275
Khalil, Shadi; Delehanty, Lorrie; Grado, Stephen et al. (2018) Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor. J Exp Med 215:661-679
Olmez, Inan; Zhang, Ying; Manigat, Laryssa et al. (2018) Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in Glioblastoma. Cancer Res 78:4360-4369
Parini, Paolo; Melhuish, Tiffany A; Wotton, David et al. (2018) Overexpression of transforming growth factor ? induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption. Atherosclerosis 275:246-255
Banizs, Anna B; Huang, Tao; Nakamoto, Robert K et al. (2018) Endocytosis Pathways of Endothelial Cell Derived Exosomes. Mol Pharm :
Jia, Deshui; Augert, Arnaud; Kim, Dong-Wook et al. (2018) Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition. Cancer Discov 8:1422-1437

Showing the most recent 10 out of 539 publications