Detailed understanding of molecular function in biological systems requires information about the 3D structures of macromolecules. The wealth of information available from such studies provides novel and powerful insights into function. Chemical biology, the modulation of protein function by small molecules, provides tool compounds to explore biological function as well as novel therapeutics for the clinic. The tools of imaging, detection, and drug delivery emerge from chemical biology efforts. The merging of the structural biology and chemical biology faculty brings together two groups that speak the same language, the language of molecular structure, making this a natural grouping. The overarching goal of the Chemical & Structural Biology (CSB) Program is to facilitate this dialogue in ways that accelerate understanding, detection, and treatment of cancer. The Program leader is John H. Bushweller, PhD, Professor of Molecular Physiology and Biological Physics, and the co-leader is Kevin R. Lynch, PhD, Professor of Pharmacology and Biochemistry & Molecular Genetics. The Program currently consists of 23 members and 6 associate members from seven different departments spanning three different schools at UVA. This includes the Chemistry Department, providing unique cross- campus opportunities to bring the power of chemistry to bear on cancer. Six of these individuals were recruited to UVA since the last renewal. Total extramural funding for the Program exceeds $12M, including over $2.4M from the NCI and over $8.7M from other NIH institutes. The group members rely heavily on Cancer Center supported infrastructure, particularly the Biomolecular Analysis Core and NMR instrumentation. Pilot grant support of CSB members has shown a clear return on investment with several NCI funded grants emerging from work supported originally with pilot grant support. The many activities and interactions have led to 276 publications, of which 18% were inter-programmatic publications and 18% were intra-programmatic publications since the last renewal.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA044579-30
Application #
10091446
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-09-16
Project End
2022-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
30
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Virginia
Department
Type
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Martins, André L; Walavalkar, Ninad M; Anderson, Warren D et al. (2018) Universal correction of enzymatic sequence bias reveals molecular signatures of protein/DNA interactions. Nucleic Acids Res 46:e9
Michaels, Alex D; Newhook, Timothy E; Adair, Sara J et al. (2018) CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer. Clin Cancer Res 24:1415-1425
Shi, Lei; Li, Kang; Guo, Yizhan et al. (2018) Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer cell-mediated control of lung cancer. Proc Natl Acad Sci U S A 115:11808-11813
Yang, Jun; LeBlanc, Francis R; Dighe, Shubha A et al. (2018) TRAIL mediates and sustains constitutive NF-?B activation in LGL leukemia. Blood 131:2803-2815
Kulling, Paige M; Olson, Kristine C; Hamele, Cait E et al. (2018) Dysregulation of the IFN-?-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. PLoS One 13:e0193429
Grant, Margaret J; Loftus, Matthew S; Stoja, Aiola P et al. (2018) Superresolution microscopy reveals structural mechanisms driving the nanoarchitecture of a viral chromatin tether. Proc Natl Acad Sci U S A 115:4992-4997
Knapp, Kiley A; Pires, Eusebio S; Adair, Sara J et al. (2018) Evaluation of SAS1B as a target for antibody-drug conjugate therapy in the treatment of pancreatic cancer. Oncotarget 9:8972-8984
Zhang, Xuewei; Kitatani, Kazuyuki; Toyoshima, Masafumi et al. (2018) Ceramide Nanoliposomes as a MLKL-Dependent, Necroptosis-Inducing, Chemotherapeutic Reagent in Ovarian Cancer. Mol Cancer Ther 17:50-59
Kedzierska, Katarzyna Z; Gerber, Livia; Cagnazzi, Daniele et al. (2018) SONiCS: PCR stutter noise correction in genome-scale microsatellites. Bioinformatics 34:4115-4117
Balogh, Kristen N; Templeton, Dennis J; Cross, Janet V (2018) Macrophage Migration Inhibitory Factor protects cancer cells from immunogenic cell death and impairs anti-tumor immune responses. PLoS One 13:e0197702

Showing the most recent 10 out of 539 publications