The Microscopy Shared Resource provides core services to Cancer Center members engaged in a wide range of scientific endeavors. Among the types of services rendered are (i) standard transmission and scanning electron microscopy, (iii) immunoelectron microscopy (enzymatic and gold labeling), (iii) fluorescence microscopy including 3-D data sets from confocal microscopy from confocal microscopy, (iv) microinjection, (v) live cell imaging, (vi) DNA spreads, and (vii) evaluation of subcellular fractionation procedures by negative staining or thin sectioning. All of thee services are highly technical and labor intensive. Without the Microscopy Shared Resource it would be extremely difficult for individual investigators to have access to these types of services which are critical to their research programs. D.L. Spector oversees the daily operation of the Shared Resources and handles any scientific or administrative problems. T. Howard is the Shared Resource Technician. She is responsible for performing experiments for Cancer Center members, training users of microscopes, and maintaining the instruments for optimum use. The Microscopy Shared Resource serves to stimulate interaction and exchange scientific approaches among Cancer Center members.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA045508-14
Application #
6348965
Study Section
Project Start
2000-09-08
Project End
2001-07-31
Budget Start
Budget End
Support Year
14
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Cold Spring Harbor Laboratory
Department
Type
DUNS #
065968786
City
Cold Spring Harbor
State
NY
Country
United States
Zip Code
11724
Krishnan, Navasona; Bonham, Christopher A; Rus, Ioana A et al. (2018) Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development. Nat Commun 9:283
Pommier, Arnaud; Anaparthy, Naishitha; Memos, Nicoletta et al. (2018) Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases. Science 360:
Krishnan, Navasona; Felice, Christy; Rivera, Keith et al. (2018) DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease. Genes Dev 32:944-952
Tiriac, Herve; Bucobo, Juan Carlos; Tzimas, Demetrios et al. (2018) Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment. Gastrointest Endosc 87:1474-1480
Nattestad, Maria; Goodwin, Sara; Ng, Karen et al. (2018) Complex rearrangements and oncogene amplifications revealed by long-read DNA and RNA sequencing of a breast cancer cell line. Genome Res 28:1126-1135
Connell, Claire M; Raby, Sophie E M; Beh, Ian et al. (2018) Cancer Immunotherapy Trials Underutilize Immune Response Monitoring. Oncologist 23:116-117
Wong, Mandy S; Kinney, Justin B; Krainer, Adrian R (2018) Quantitative Activity Profile and Context Dependence of All Human 5' Splice Sites. Mol Cell 71:1012-1026.e3
Snider, Justin M; Snider, Ashley J; Obeid, Lina M et al. (2018) Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry. J Lipid Res 59:1046-1057
Stacchiotti, Silvia; Mir, Olivier; Le Cesne, Axel et al. (2018) Activity of Pazopanib and Trabectedin in Advanced Alveolar Soft Part Sarcoma. Oncologist 23:62-70
Banito, Ana; Li, Xiang; Laporte, Aimée N et al. (2018) The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. Cancer Cell 33:527-541.e8

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