The Microarray Shared Resource allows the CSHL Cancer Center members to take advantage of powerful genomics tools and techniques. The Shared Resource provides full service microarray analysis, primarily focusing on the Affymetrix and Agilent platforms. The microarray applications used by the facility provide RNA profiling, genome analysis of copy number variation and insights into DNA/protein interactions and chromatin modifications by means of chromatin immunoprecipitation. The use of Microarray services has promoted and strengthened multidisciplinary interactions with the Bioinformatics and DNA Sequencing Shared Resources. Microarrays provide a low resolution, genome-wide view of changes in gene expression in different cell types or under different conditions, which serve as a starting point for pathway analysis and the identification of key regions of variation in cancer gene discovery experiments. In many cases, microarray experiments can be a prelude to high throughput sequencing and can help focus the sequencing efforts.
The Microarray Shared Resource provides an essential and cost effective complement to the other methodologies used at CSHL to characterize genomes and transcriptomes, most notably high-throughput sequencing.
| Tiriac, Hervé; Belleau, Pascal; Engle, Dannielle D et al. (2018) Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov 8:1112-1129 |
| Naguib, Adam; Mathew, Grinu; Reczek, Colleen R et al. (2018) Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells. Cell Rep 23:58-67 |
| Forcier, Talitha L; Ayaz, Andalus; Gill, Manraj S et al. (2018) Measuring cis-regulatory energetics in living cells using allelic manifolds. Elife 7: |
| Bhagwat, Anand S; Lu, Bin; Vakoc, Christopher R (2018) Enhancer dysfunction in leukemia. Blood 131:1795-1804 |
| Aberle, M R; Burkhart, R A; Tiriac, H et al. (2018) Patient-derived organoid models help define personalized management of gastrointestinal cancer. Br J Surg 105:e48-e60 |
| Chen, Wei-Chia; Tareen, Ammar; Kinney, Justin B (2018) Density Estimation on Small Data Sets. Phys Rev Lett 121:160605 |
| Khan, Jalal A; Maki, Robert G; Ravi, Vinod (2018) Pathologic Angiogenesis of Malignant Vascular Sarcomas: Implications for Treatment. J Clin Oncol 36:194-201 |
| Albrengues, Jean; Shields, Mario A; Ng, David et al. (2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 361: |
| Cheng, Derek; Tuveson, David (2018) Kras in Organoids. Cold Spring Harb Perspect Med 8: |
| Melnikov, Sergey V; Rivera, Keith D; Ostapenko, Denis et al. (2018) Error-prone protein synthesis in parasites with the smallest eukaryotic genome. Proc Natl Acad Sci U S A 115:E6245-E6253 |
Showing the most recent 10 out of 380 publications
