The Proteomics Shared Resource (PSR) is a specialized technical facility with the primary goal of protein identification, characterization and quantitation, and is open to all Cancer Center members at CSHL. The Proteomics Shared Resource is located within the W.M. Keck Structural Biology Laboratory on the ground floor ofthe Beckman building. In the last 18 months CSHL has completed a major restructuring ofthe Resource. A senior faculty member with significant expertise in proteomics was recruited to redesign and oversee the Shared Resource. In addition, a PhD-level scientist with experience in proteomics and mass spectrometry was recruited to manage and run the facility. With the new staff in place, state-of-the-art equipment was purchased and the laboratory space was extensively renovated. The Resource features new, state-of-the-art equipment, including: one Thermo LTQ-Orbitrap mass spectrometer, one Thermo LTQ iontrap mass spectrometer, one Agilent 6520 quadrupole time-of-flight (QTOF) mass spectrometer and one Thermo Vantage triple quadrupole mass spectrometer, all fitted with nano electrospray (NanoESl) sources. A second Orbitrap Velos mass spectrometer with ETD source (funded through the High-End Instrumentation program) is due to be installed in late 2010. An additional Accela HPLC and autosampler is also available for analytical scale MRM work using the Vantage triple-Quad.

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National Cancer Institute (NCI)
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Subcommittee G - Education (NCI)
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Cold Spring Harbor Laboratory
Cold Spring Harbor
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Pommier, Arnaud; Anaparthy, Naishitha; Memos, Nicoletta et al. (2018) Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases. Science 360:
Krishnan, Navasona; Bonham, Christopher A; Rus, Ioana A et al. (2018) Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development. Nat Commun 9:283
Tiriac, Herve; Bucobo, Juan Carlos; Tzimas, Demetrios et al. (2018) Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment. Gastrointest Endosc 87:1474-1480
Krishnan, Navasona; Felice, Christy; Rivera, Keith et al. (2018) DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease. Genes Dev 32:944-952
Connell, Claire M; Raby, Sophie E M; Beh, Ian et al. (2018) Cancer Immunotherapy Trials Underutilize Immune Response Monitoring. Oncologist 23:116-117
Nattestad, Maria; Goodwin, Sara; Ng, Karen et al. (2018) Complex rearrangements and oncogene amplifications revealed by long-read DNA and RNA sequencing of a breast cancer cell line. Genome Res 28:1126-1135
Snider, Justin M; Snider, Ashley J; Obeid, Lina M et al. (2018) Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry. J Lipid Res 59:1046-1057
Wong, Mandy S; Kinney, Justin B; Krainer, Adrian R (2018) Quantitative Activity Profile and Context Dependence of All Human 5' Splice Sites. Mol Cell 71:1012-1026.e3
Banito, Ana; Li, Xiang; Laporte, Aimée N et al. (2018) The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. Cancer Cell 33:527-541.e8
Stacchiotti, Silvia; Mir, Olivier; Le Cesne, Axel et al. (2018) Activity of Pazopanib and Trabectedin in Advanced Alveolar Soft Part Sarcoma. Oncologist 23:62-70

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