This grant is a resubmission of a Core grant request for the University of Michigan Cancer Center. The application has been revised based on the suggestions of the previous NCI Center Support Review Committee. The University of Michigan Cancer Center (UMCC) was established by the Board of Regents in May 1986 to provide a focus for all of the cancer related activities throughout the University. The strategy of the Cancer Center is to provide an organizational framework to promote and enhance interdisciplinary research throughout the University. This is accomplished through the development of defined clinical and basic science interdisciplinary programs in cancer research and the development and support of shared core resources. There are seven clinical research programs in the UMCC. These represent coordinated research efforts in cancers of major organ systems including head and neck, breast, chest, genito-urinary, central nervous system, leukemia and lymphoma, and pediatric tumors. The six basic science research programs of the Center include tumor metastasis and the extracellular matrix, molecular mechanisms of gene regulation, tumor immunology, cancer pharmacology, drug development, and cancer epidemiology causation and prevention. The UMCC has established 10 shared core facilities which include a clinical trials office, biostatistics, tissue procurement, tumor imaging, pharmacokinetics, drug analysis, molecular biology, peptide synthesis, morphology and cytometry cores. The University has committed significant resources to the Cancer Center for the support of Center programs and shared core facilities. Dr. Wicha, Center Director, has responsibility for managing the affairs of the Center. He has authority and responsibility for space, equipment, budgets, and personnel assigned to the Center in addition to responsibility for coordinating Center Basic Research and Clinical Research Programs. The 216 faculty with appointments to the UMCC currently receive over 21 million dollars annually in grant support. The UMCC has had a major impact on cancer research at the University of Michigan.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
1P30CA046592-01A1
Application #
3101838
Study Section
Cancer Center Support Grant Review Committee (CCS)
Project Start
1988-09-30
Project End
1991-06-30
Budget Start
1988-09-30
Budget End
1989-06-30
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Khoriaty, Rami; Hesketh, Geoffrey G; Bernard, Amélie et al. (2018) Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo. Proc Natl Acad Sci U S A 115:E7748-E7757
Katz, Steven J; Ward, Kevin C; Hamilton, Ann S et al. (2018) Gaps in Receipt of Clinically Indicated Genetic Counseling After Diagnosis of Breast Cancer. J Clin Oncol 36:1218-1224
Ulintz, Peter J; Greenson, Joel K; Wu, Rong et al. (2018) Lymph Node Metastases in Colon Cancer Are Polyclonal. Clin Cancer Res 24:2214-2224
Qin, Tingting; Zhang, Yanxiao; Zarins, Katie R et al. (2018) Expressed HNSCC variants by HPV-status in a well-characterized Michigan cohort. Sci Rep 8:11458
Xu, Shilin; Aguilar, Angelo; Xu, Tianfeng et al. (2018) Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl 57:1601-1605
Crespo, Joel; Wu, Ke; Li, Wei et al. (2018) Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis. J Immunol 201:814-820
Manohar, Poorni M; Beesley, Lauren J; Bellile, Emily L et al. (2018) Prognostic Value of FDG-PET/CT Metabolic Parameters in Metastatic Radioiodine-Refractory Differentiated Thyroid Cancer. Clin Nucl Med 43:641-647
Hawley, Sarah T; Li, Yun; An, Lawrence C et al. (2018) Improving Breast Cancer Surgical Treatment Decision Making: The iCanDecide Randomized Clinical Trial. J Clin Oncol 36:659-666
Salami, Simpa S; Hovelson, Daniel H; Kaplan, Jeremy B et al. (2018) Transcriptomic heterogeneity in multifocal prostate cancer. JCI Insight 3:
Smith, Joshua; Kulkarni, Aditi; Birkeland, Andrew C et al. (2018) Whole-Exome Sequencing of Sinonasal Small Cell Carcinoma Arising within a Papillary Schneiderian Carcinoma In Situ. Otolaryngol Head Neck Surg 159:859-865

Showing the most recent 10 out of 1493 publications