Abstract

The Experimental Therapeutics Program was formed in September 1999 with the goal of developing the translation of laboratory and medial physics discoveries into clinical trials. The Program has 37 members from seven departments who receive over $6.7 million in annual direct support. Research is focused in three areas: Radiation enhancement, which includes studies of drug-radiation interactions and medical physics underlying 3D and intensity modulated radiation therapy planning and delivery. Mechanisms of drug-radiation interactions are studied at the molecular, cellular, and tumor level, and include both studies with small molecules and gene therapy. Molecular and functional imaging, which includes developing imaging techniques for molecular processes (such as apoptosis) and as predictive assays (such as magnetic resonance diffusion). Cancer Pharmacology, developed to monitor biologic effect, focused on development of specific agents targeting aberrant molecular events of early or developed cancer cells as well as methods of genetic prediction of drug toxicity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA046592-15
Application #
6597029
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
2002-06-01
Project End
2003-05-31
Budget Start
Budget End
Support Year
15
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Holt, Melissa C; Assar, Zahra; Beheshti Zavareh, Reza et al. (2018) Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry 57:6604-6614
Jiagge, Evelyn; Jibril, Aisha Souleiman; Davis, Melissa et al. (2018) Androgen Receptor and ALDH1 Expression Among Internationally Diverse Patient Populations. J Glob Oncol :1-8
Bowers, Emily; Slaughter, Anastasiya; Frenette, Paul S et al. (2018) Granulocyte-derived TNF? promotes vascular and hematopoietic regeneration in the bone marrow. Nat Med 24:95-102
O'Dwyer, David N; Zhou, Xiaofeng; Wilke, Carol A et al. (2018) Lung Dysbiosis, Inflammation, and Injury in Hematopoietic Cell Transplantation. Am J Respir Crit Care Med 198:1312-1321
Wang, Yin; Day, Mark L; Simeone, Diane M et al. (2018) 3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer. J Vis Exp :
Suresh, Krithika; Owen, Dawn; Bazzi, Latifa et al. (2018) Using Indocyanine Green Extraction to Predict Liver Function After Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys 100:131-137
Xiong, Yi; Torsoni, Adriana Souza; Wu, Feihua et al. (2018) Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. Elife 7:
El Kadi, Najwa; Wang, Luo; Davis, April et al. (2018) The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer. Cancer Res 78:6728-6735
Feng, Mary; Suresh, Krithika; Schipper, Matthew J et al. (2018) Individualized Adaptive Stereotactic Body Radiotherapy for Liver Tumors in Patients at High Risk for Liver Damage: A Phase 2 Clinical Trial. JAMA Oncol 4:40-47
Thomas, Tina T; Chukkapalli, Sahiti; Van Noord, Raelene A et al. (2018) Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts. J Vis Exp :

Showing the most recent 10 out of 1493 publications