Program Leaders

Fearon, Eric R.

Abstract

Program Directors Cancer Centers exist to foster cancer-focused research, in part through the creation of formal Programs. A program comprises the activities of a group of investigators who share common scientific interests and goals and participate in competitively funded research. The 13 programs in the UMCCC Cancer Center Support Grant are highly interactive and lead to exchange of information, experimental techniques, and ideas that enhance the individual productivity of scientists and often result in collaborations and joint publications. Ultimately, the success of Programs is measured by the emergence of productive collaborations. The 13 programs are: Cancer Genetics, Cancer Cell Biology, Molecular Therapeutics, Radiation Sciences, Molecular Imaging, Leukemia/Lymphoma-BMT, Breast Oncology, Prostate/Urologic Oncology, Gastrointestinal Oncology, Childhood Cancers, Head and Neck Oncology, Biomedical Prevention and Socio-Behavioral.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 5P30CA046592-20
• Application #: 7726796
• Study Section: Subcommittee G - Education (NCI)
• Budget Start: 2007-06-01
• Budget End: 2008-05-31
• Support Year: 20
• Fiscal Year: 2007
• Total Cost: $247,099

Institution

• Name: University of Michigan Ann Arbor
• DUNS #: 073133571
• City: Ann Arbor
• State: MI
• Country: United States
• Zip Code: 48109

Publications

Feinberg, Tamar Y; Zheng, Huarui; Liu, Rui et al. (2018) Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs. Dev Cell 47:145-160.e6

Boonstra, Philip S; Barbaro, Ryan P (2018) Incorporating historical models with adaptive Bayesian updates. Biostatistics :

Johnson, Allison M; Roach, James P; Hu, Anna et al. (2018) Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure. FASEB J 32:2615-2629

Sucularli, Ceren; Thomas, Peedikayil; Kocak, Hande et al. (2018) High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype. Gene 679:219-231

Hrycaj, Steven M; Marty-Santos, Leilani; Cebrian, Cristina et al. (2018) Hox5 genes direct elastin network formation during alveologenesis by regulating myofibroblast adhesion. Proc Natl Acad Sci U S A 115:E10605-E10614

Subramanian, Chitra; Grogan, Patrick T; Opipari, Valerie P et al. (2018) Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt/mTOR/NF-?B activation. Oncotarget 9:14509-14523

Wang, Qing; Yan, Ran; Pinnell, Nancy et al. (2018) Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development. Blood 132:1279-1292

Owen, Daniel Rocky; Boonstra, Phillip S; Viglianti, Benjamin L et al. (2018) Modeling Patient-Specific Dose-Function Response for Enhanced Characterization of Personalized Functional Damage. Int J Radiat Oncol Biol Phys 102:1265-1275

Dame, Michael K; Attili, Durga; McClintock, Shannon D et al. (2018) Identification, isolation and characterization of human LGR5-positive colon adenoma cells. Development 145:

Abel, Ethan V; Goto, Masashi; Magnuson, Brian et al. (2018) HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties. Elife 7: