(CANCER EPIDEMIOLOGY AND PREVENTION) The Cancer Epidemiology and Prevention (CEP) Program is a group of interdisciplinary population health and medical scientists that conduct research to elucidate environmental, lifestyle and genetic causes of cancer, and develop and test strategies and interventions to prevent and reduce the risk of cancer. CEP program members also focus on developing statistical and mathematical approaches to advance cancer research. The program is comprised of 29 members from 17 different departments and three schools with total annual direct research support of $5.8 million - of which $4.7 million (81%) is from the NCI. Members are highly productive, with 533 publications during the project period, of which 17.4% are intra-programmatic and 35.3% are inter- programmatic. Investigators are involved in intra- and inter-programmatic interactions and actively collaborate with researchers in the other University of Michigan Comprehensive Cancer Center programs. The CEP program has three main specific aims: 1) Elucidate risk and protective factors for common and high-mortality cancers, with a focus on lifestyle, environmental and molecular exposures; 2) Discover and implement primary, secondary and tertiary prevention strategies incorporating environmental and personal exposures and state-of- the-art genomic, proteomic, metabolomic, and imaging biotechnologies; and 3) Develop and operationalize novel biostatistical and analytic methods for big data and personalized prevention and screening.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA046592-30
Application #
9744587
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
30
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Harvey, Innocence; Stephenson, Erin J; Redd, JeAnna R et al. (2018) Glucocorticoid-Induced Metabolic Disturbances Are Exacerbated in Obese Male Mice. Endocrinology 159:2275-2287
Schuetze, Scott M; Bolejack, Vanessa; Thomas, Dafydd G et al. (2018) Association of Dasatinib With Progression-Free Survival Among Patients With Advanced Gastrointestinal Stromal Tumors Resistant to Imatinib. JAMA Oncol 4:814-820
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Schofield, Heather K; Tandon, Manuj; Park, Min-Jung et al. (2018) Pancreatic HIF2? Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cell Mol Gastroenterol Hepatol 5:169-185.e2
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Moody, Rebecca Reed; Lo, Miao-Chia; Meagher, Jennifer L et al. (2018) Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes. J Biol Chem 293:2125-2136
Ma, Vincent T; Boonstra, Philip S; Menghrajani, Kamal et al. (2018) Treatment With JAK Inhibitors in Myelofibrosis Patients Nullifies the Prognostic Impact of Unfavorable Cytogenetics. Clin Lymphoma Myeloma Leuk 18:e201-e210
Collins, Dalis; Fry, Christopher; Moore, Bethany B et al. (2018) Phagocytosis by Fibrocytes as a Mechanism to Decrease Bacterial Burden and Increase Survival in Sepsis. Shock :
Hawkins, Allegra G; Basrur, Venkatesha; da Veiga Leprevost, Felipe et al. (2018) The Ewing Sarcoma Secretome and Its Response to Activation of Wnt/beta-catenin Signaling. Mol Cell Proteomics 17:901-912

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