Abstract

) The Radiological Sciences core was one of the original cores established at the inception of the University of Colorado Cancer Center in 1988 to provide centralized facilities, training, and expertise for cancer research involving the use of ionizing radiation including irradiation facilities, preparation of radiolabeled cells and antibodies for cancer diagnosis and treatment, radiation dosimetry, and diagnostic imaging consultation services. Cancer center member usage of the 60 Co irradiator has been stable over the last five years and has increased by about 50% for 1999. Radiolabeling services have been used primarily for monoclonal antibody labeling for radioimmunotherapy. This function is projected to increase due to the FDA approval of new antibodies and recruitment of new faculty. Dosimetry consultation services have focused on radiolabeled monoclonal antibodies for radioimmunotherapy as well. The transition to our new campus at Fitzsimons is expected to increase the need for additional facilities for irradiation as Cancer Center members move their research activities to the new site. In addition, the new cyclotron and PET capabilities are expected to increase research opportunities and the involvement of the Radiological Sciences core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA046934-14
Application #
6478752
Study Section
Project Start
1988-03-01
Project End
2006-01-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
14
Fiscal Year
2001
Total Cost
$144,004
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Maccini, Michael A; Westfall, Nicholas J; Van Bokhoven, Adrie et al. (2018) The effect of digital rectal exam on the 4Kscore for aggressive prostate cancer. Prostate 78:506-511
Ye, Haobin; Adane, Biniam; Khan, Nabilah et al. (2018) Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Cancer Cell 34:659-673.e6
Flannery, Patrick C; DeSisto, John A; Amani, Vladimir et al. (2018) Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma. Oncol Rep 39:455-464
Elder, Alan M; Tamburini, Beth A J; Crump, Lyndsey S et al. (2018) Semaphorin 7A Promotes Macrophage-Mediated Lymphatic Remodeling during Postpartum Mammary Gland Involution and in Breast Cancer. Cancer Res 78:6473-6485
Yue, Zongliang; Zheng, Qi; Neylon, Michael T et al. (2018) PAGER 2.0: an update to the pathway, annotated-list and gene-signature electronic repository for Human Network Biology. Nucleic Acids Res 46:D668-D676
Smith, Weston J; Tran, Huy; Griffin, James I et al. (2018) Lipophilic indocarbocyanine conjugates for efficient incorporation of enzymes, antibodies and small molecules into biological membranes. Biomaterials 161:57-68
Morgan, Michael J; Fitzwalter, Brent E; Owens, Charles R et al. (2018) Metastatic cells are preferentially vulnerable to lysosomal inhibition. Proc Natl Acad Sci U S A 115:E8479-E8488
Hartwick, Erik W; Costantino, David A; MacFadden, Andrea et al. (2018) Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels. Nat Commun 9:5074
Genova, Carlo; Socinski, Mark A; Hozak, Rebecca R et al. (2018) EGFR Gene Copy Number by FISH May Predict Outcome of Necitumumab in Squamous Lung Carcinomas: Analysis from the SQUIRE Study. J Thorac Oncol 13:228-236
Greer, Robert O; Eskendri, Jeffrey; Freedman, Paul et al. (2018) Assessment of biologically aggressive, recurrent glandular odontogenic cysts for mastermind-like 2 (MAML2) rearrangements: histopathologic and fluorescent in situ hybridization (FISH) findings in 11 cases. J Oral Pathol Med 47:192-197

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