Abstract

) The University of Pittsburgh Cancer Institute (UPCI) Informatics Facility provides information technology support to UPCI members involved in cancer-related research. The overall goal of the Facility is to develop and implement a next generation information technology infrastructure within UPCI that will support the research activities of UPCI members. The Facility is currently developing a sophisticated information system and secure intranet that will eventually acquire, store and manage all research data generated at UPCI. The Informatics Facility currently manages all data generated by UPCI cancer research protocols in addition to highly specialized data generated by UPCI research laboratories, such as the Immunologic Monitoring and Diagnostic Laboratory (IMDL). Facility personnel work closely with many UPCI programs on issues related to information technology support in both the clinical and research domains. The Facility Director chairs UPCI's Information Systems Steering Committee.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA047904-12
Application #
6212133
Study Section
Subcommittee G - Education (NCI)
Project Start
1988-08-01
Project End
2004-07-30
Budget Start
Budget End
Support Year
12
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Kumar, Dhruv; New, Jacob; Vishwakarma, Vikalp et al. (2018) Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression. Cancer Res 78:3769-3782
Weir, Mark C; Shu, Sherry T; Patel, Ravi K et al. (2018) Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. ACS Chem Biol 13:1551-1559
Chakraborty, Souvik; Jiang, Chang; Gau, David et al. (2018) Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells. Br J Cancer 119:1106-1117
Lu, Shanhong; Concha-Benavente, Fernando; Shayan, Gulidanna et al. (2018) STING activation enhances cetuximab-mediated NK cell activation and DC maturation and correlates with HPV+ status in head and neck cancer. Oral Oncol 78:186-193
Song, Xinxin; Lee, Dae-Hee; Dilly, Ashok-Kumar et al. (2018) Crosstalk Between Apoptosis and Autophagy Is Regulated by the Arginylated BiP/Beclin-1/p62 Complex. Mol Cancer Res 16:1077-1091
Chen, Dongshi; Tong, Jingshan; Yang, Liheng et al. (2018) PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A 115:3930-3935
Teng, Yaqun; Yadav, Tribhuwan; Duan, Meihan et al. (2018) ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun 9:4115
Nguyen, Nghi C; Yee, Melissa K; Tuchayi, Abuzar M et al. (2018) Targeted Therapy and Immunotherapy Response Assessment with F-18 Fluorothymidine Positron-Emission Tomography/Magnetic Resonance Imaging in Melanoma Brain Metastasis: A Pilot Study. Front Oncol 8:18
Hartmaier, R J; Trabucco, S E; Priedigkeit, N et al. (2018) Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer. Ann Oncol 29:872-880
Palliyaguru, Dushani L; Yuan, Jian-Min; Kensler, Thomas W et al. (2018) Isothiocyanates: Translating the Power of Plants to People. Mol Nutr Food Res 62:e1700965

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