Abstract

The Basic Genomics and Proteomics Facility(BGPF) is a newly proposed core to provide state-of-the-art genomic and proteomic technologies to UPCI investigators for basic research applications. The services encompass a wide range of technologies including cytogenetics, DNA sequencing, DNA and RNA isolation, Serial Analysis of Gene Expression (SAGE) library production, SNP genotyping, STRP genotyping, Array analysis (Affymetrix, CodeLink, and custom arrays), Quantitative RT-PCR, Difference Gel Electrophoresis, Ciphergen Proteinchip Profiling, Protein identification and sequencing.
The specific aims of the BGPF are: 1. To provide access to genomics technologies for basic cancer research and help investigators determine which technologies are most applicable for their research. 2. To provide access to proteomics technologies for basic cancer research and help investigators determine which technologies are most applicable for their research. 3. To provide access to tools and expertise in genomic and proteomic data analysis and interpretation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA047904-18
Application #
7111836
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
18
Fiscal Year
2005
Total Cost
$124,564
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Low, Carissa A; Bovbjerg, Dana H; Ahrendt, Steven et al. (2018) Fitbit step counts during inpatient recovery from cancer surgery as a predictor of readmission. Ann Behav Med 52:88-92
Correa, Andres F; Toussi, Amir; Amin, Milon et al. (2018) Small Renal Masses in Close Proximity to the Collecting System and Renal Sinus Are Enriched for Malignancy and High Fuhrman Grade and Should Be Considered for Early Intervention. Clin Genitourin Cancer 16:e729-e733
Wang, Yi-Jun; Fletcher, Rochelle; Yu, Jian et al. (2018) Immunogenic effects of chemotherapy-induced tumor cell death. Genes Dis 5:194-203
Bakkenist, Christopher J; Lee, James J; Schmitz, John C (2018) ATM Is Required for the Repair of Oxaliplatin-Induced DNA Damage in Colorectal Cancer. Clin Colorectal Cancer 17:255-257
Beumer, Jan H; Chu, Edward; Allegra, Carmen et al. (2018) Therapeutic Drug Monitoring in Oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology Recommendations for 5-Fluorouracil Therapy. Clin Pharmacol Ther :
Tasdemir, Nilgun; Bossart, Emily A; Li, Zheqi et al. (2018) Comprehensive Phenotypic Characterization of Human Invasive Lobular Carcinoma Cell Lines in 2D and 3D Cultures. Cancer Res 78:6209-6222
Mazharuddin, Samir; Chattopadhyay, Anuja; Levy, Moshe Y et al. (2018) IRF2BP2-RARA t(1;17)(q42.3;q21.2) APL blasts differentiate in response to all-trans retinoic acid. Leuk Lymphoma 59:2246-2249
Basudan, Ahmed; Priedigkeit, Nolan; Hartmaier, Ryan J et al. (2018) Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer. Mol Cancer Res :
Pascal, Laura E; Wang, Yao; Zhong, Mingming et al. (2018) EAF2 and p53 Co-Regulate STAT3 Activation in Prostate Cancer. Neoplasia 20:351-363
Song, Xinxin; Zhu, Shan; Chen, Pan et al. (2018) AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc- Activity. Curr Biol 28:2388-2399.e5

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